Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals

被引：9

作者：

Morita, Hiroshi ^{[1
]}

Nishino, Hitomi ^{[1
]}

Nakajima, Yuki ^{[1
]}

Kakubari, Yoshiaki ^{[1
]}

Nakata, Asami ^{[1
]}

Deguchi, Jun ^{[1
]}

Nugroho, Alfarius Eko ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Kaneda, Toshio ^{[1
]}

Kawasaki, Yoko ^{[2
]}

Goda, Yukihiro ^{[2
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Tokyo 1428501, Japan

[2] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2015年 / 69卷 / 04期

基金：

日本学术振兴会;

关键词：

Oxomollugin; Mollugin; LPS; RAW264.7; iNOS; NO; Inflammation; MOLLUGIN; CORDIFOLIA; APOPTOSIS; INNATE;

D O I：

10.1007/s11418-015-0927-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mollugin, a naphthoquinone derivative, was reported to possess various biological activities such as anti-inflammatory and anti-tumor activity. Mollugin isolated from Rubia tinctorum roots inhibited lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 macrophages. However, mollugin synthesized for further investigation of its anti-inflammatory mechanism showed weak activity in addition to unstable assay results. From the result of analysis on a degradation product of mollugin, oxomollugin was found to be the main active substance of mollugin degradation, showing a potent inhibitory activity on NO-production including nuclear factor kappa B signals.

引用

页码：608 / 611

页数：4

共 19 条

[1] Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo [J].