Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the US concurrently infected with PPV2

被引:102
作者
Opriessnig, Tanja [1 ]
Xiao, Chao-Ting [1 ]
Gerber, Priscilla F. [1 ]
Halbur, Patrick G. [1 ]
机构
[1] Iowa State Univ, Coll Vet Med, Dept Vet Diagnost & Prod Anim Med, Ames, IA 50011 USA
关键词
Porcine circovirus type 2 (PCV2); Vaccination; Mutant PCV2; Porcine parvovirus type 2 (PPV2); PORCINE CIRCOVIRUS TYPE-2; PARVOVIRUS; SWINE; IDENTIFICATION; PREVALENCE; GENOTYPES; DISEASE; PMWS;
D O I
10.1016/j.vetmic.2012.12.019
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Porcine circovirus (PCV) type 2b (PCV2b) emerged in North America in 2005-2006. During May of 2012, PCVAD occurred in 10-18-week-old pigs in two farms within a production system that routinely vaccinated against PCV2. Both farms received replacement gilts from the same multiplier. A mutant PCV2b strain not previously present in North America was identified. The strain was found to be 99.9% identical to a recently described mutant PCV2 isolate reported in China in 2010 and thought to be more virulent than classical PCV2a or PCV2b strains. It is possible that the current PCV2a-based commercial vaccines are not fully protective against this new strain. In addition, emerging porcine parvovirus type 2 (PPV2) was detected in 55% of the serum samples (73/132), perhaps implying that PPV2 could be a cofactor in cases of PCVAD. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:177 / 183
页数:7
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