Clinical potential and putative risks of fertility preservation in children utilizing gonadal tissue or germline stem cells

被引：50
作者：
Jahnukainen, K [1 ]
Ehmcke, J
Söder, O
Schlatt, S
机构：
[1] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Ctr Res Reprod Physiol, Pittsburgh, PA 15261 USA
[2] Univ Turku, Dept Pediat, FIN-20520 Turku, Finland
[3] Karolinska Inst, Pediat Endocrinol Unit, Dept Woman & Child Hlth, SE-17176 Stockholm, Sweden
[4] Univ Hosp, SE-17176 Stockholm, Sweden
来源：
PEDIATRIC RESEARCH | 2006年 / 59卷 / 04期
关键词：
D O I：
10.1203/01.pdr.0000205153.18494.3b
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Rapid progress in the development of novel experimental strategies to generate fertile gametes from cryo-preserved ovarian and testicular tissue motivates oncologists to investigate ways in which gonadal tissue might be preserved. Childhood cancer patients remain the major pediatric group which can benefit from these techniques. Other potential candidates include patients with systemic diseases, which require gonadotoxic chemotherapy, patients undergoing gonadectomy, patients with Turner or Kleinefelter's syndrome, and boys with cryptorchid testes. This review aims to present an overview of the current state of knowledge in experimental germ stem cell transplantation in higher primates including humans, and the clinical risks and limitations related to such procedures in children. This area of research is discussed in the context of the potential future options that may become available for preserving fertility in boys and girls.
引用
收藏
页码：40R / 47R
页数：8
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