Effect of Zoledronic Acid on Reducing Femoral Bone Mineral Density Loss following Total Hip Arthroplasty Preliminary Results of a Prospective Randomized Trial

被引：30
作者：
Scott, David F. [1 ]
Woltz, Jennifer N. [1 ]
Smith, Rachel R. [1 ]
机构：
[1] Spokane Joint Replacement Ctr Inc, Spokane, WA 99218 USA
来源：
JOURNAL OF ARTHROPLASTY | 2013年 / 28卷 / 04期
关键词：
total hip arthroplasty; bone mineral density; bisphosphonates; X-RAY ABSORPTIOMETRY; PARTICLE-INDUCED OSTEOLYSIS; DOUBLE-BLIND; IMPLANT MIGRATION; ALENDRONATE; PAMIDRONATE; BISPHOSPHONATES; PREVENTION; RESORPTION;
D O I：
10.1016/j.arth.2012.08.007
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
This randomized trial evaluated the effect of zoledronic acid on femoral bone mineral density (BMD) following primary total hip arthroplasty. Bone mineral density was compared for up to 2 years in 27 patients receiving 5 mg zoledronic acid intravenous infusion and in 24 patients receiving placebo at 2 weeks and 1 year after surgery. Zoledronic acid prevented loss of bone mineral density at 1 year (+13.8% vs +1.4%, P=.0065) and 2years (+14.3% vs -4.0%, P<.0001) in Gruen zone 1, at 1 year (-8.4% vs -25.4%, P<.0001) and 2years (-9.6% vs -27.3%, P<.0001) in Gruen zone 7, at 6weeks, 6 months, and 1 or 2 years in Gruen zones 4 and 6. For all Gruen zones, prevention of BMD loss by ZOL was significant at 6weeks, 6 months, 1 year (+0.80% vs -6.03%, P<.0001) and 2years (-0.16% vs -7.13%, P<.0001). (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：671 / 675
页数：5
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