Sex Cord Tumor With Annular Tubules-Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant

被引：4

作者：

Chang, Ruby J. ^{[1
]}

Reuther, Jacquelyn ^{[1
,2
]}

Gandhi, Ilavarasi ^{[1
,2
]}

Roy, Angshumoy ^{[1
,2
]}

Jain, Shilpa ^{[1
,3
]}

Masand, Ramya P. ^{[1
,3
]}

机构：

[1] Baylor Coll Med, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Houston, TX 77030 USA

[3] Ben Taub Gen Hosp, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2021年 / 29卷 / 04期

关键词：

sex cord tumor with annular tubules; SCTAT; adult granulosa cell tumor; AGCT; FOXL2;

D O I：

10.1177/1066896920953620

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypicalFOXL2p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern.

引用

页码：433 / 437

页数：5

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