Microbial translocation, immune activation, and HIV disease

被引：291

作者：

Klatt, Nichole R. ^{[1
]}

Funderburg, Nicholas T. ^{[2
]}

Brenchley, Jason M. ^{[1
]}

机构：

[1] NIAID, Mol Microbiol Lab, Program Barrier Immun & Repair, NIH, Bethesda, MD 20892 USA

[2] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Ctr AIDS Res, Div Infect Dis, Cleveland, OH USA

来源：

TRENDS IN MICROBIOLOGY | 2013年 / 21卷 / 01期

关键词：

HIV; microbial translocation; immune activation; mucosal immunity; T-CELL-ACTIVATION; PLASMACYTOID DENDRITIC CELLS; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; SIV INFECTION; COAGULATION BIOMARKERS; VIROLOGICAL RESPONSES; IL-17; PRODUCTION; NATURAL HOSTS; CD4(+);

D O I：

10.1016/j.tim.2012.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The advent of combination antiretroviral therapy (cART) has significantly improved the prognosis of human immunodeficiency virus (HIV)-infected individuals. However, individuals treated long-term with cART still manifest increased mortality compared to HIV-uninfected individuals. This increased mortality is closely associated with inflammation, which persists in cART-treated HIV-infected individuals despite levels of plasma viremia below detection limits. Chronic, pathological immune activation is a key factor in progression to acquired immunodeficiency syndrome (AIDS) in untreated HIV-infected individuals. One contributor to immune activation is microbial translocation, which occurs when microbial products traverse the tight epithelial barrier of the gastrointestinal tract. Here we review the mechanisms underlying microbial translocation and its role in contributing to immune activation and disease progression in HIV infection.

引用

页码：6 / 13

页数：8

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