Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters

被引：28

作者：

Dolfen, Daniel ^{[1
]}

Schottler, Kristina ^{[1
]}

Valiahdi, Seied-Mojtaba ^{[2
]}

Jakupec, Michael A. ^{[2
]}

Keppler, Bernhard K. ^{[2
]}

Tiekink, Edward R. T. ^{[3
]}

Mohr, Fabian ^{[1
]}

机构：

[1] Berg Univ Wuppertal, Fachbereich C Anorgan Chem, D-42119 Wuppertal, Germany

[2] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[3] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2008年 / 102卷 / 12期

关键词：

Platinum complexes; Thiocarbamate ester ligands; Water-soluble phosphine ligands; Cytotoxicity;

D O I：

10.1016/j.jinorgbio.2008.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thiocarbamate esters 4-RC6H4NHC(S)OMe (R = H, Cl, OMe, NO2, Me) react with cis-[PtCl2(PTA)(2)] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the platinum(II) complexes trans-[Pt[SC(OMe)=NC6H4R)(2)(PTA)(2)] (R = H, Cl, OMe, NO2, Me) in high yields. The complexes were fully characterised spectroscopically and, in case of the NO2 derivate, by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in four human cancer cell lines (CH1, HT29, A549, SK-OV-3) using the MTT assay. The results show that the Cl substituted derivate is the most potent of these compounds in vitro. Moreover, this derivative is capable of partially circumventing primary cisplatin resistance in ovarian and colon carcinoma cells. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：2067 / 2071

页数：5

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