Synthesis and transformations of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea

被引：1
|
作者：
Eliazyan, Karine [1 ]
Hakobyan, Ruzanna [1 ]
Pivazyan, Vergush [1 ]
Ghazaryan, Emma [1 ]
Yengoyan, Aleksandr [1 ,2 ]
机构：
[1] Armenian Natl Agr Univ, Yerevan 0009, Armenia
[2] Armenian Russian Slavon State Univ, Yerevan 0051, Armenia
来源：
HETEROCYCLIC COMMUNICATIONS | 2013年 / 19卷 / 02期
关键词：
heterocyclization; 1,3,4-oxadiazoles; 1,3,4-thiadiazoles; thiazole; 1-[2-(toluene-4-sulfonamido)ethyl]thiourea;
D O I：
10.1515/hc-2013-0005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Readily available 2-(toluene-4-sulfonylamino)ethylamine is a convenient starting material for a two-step synthesis of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea (2). Heterocyclization of the thiourea moiety in 2 furnished a thiazole derivative 3 which was further functionalized into substituted thiazoles 4-6. A series of 2-(thiazol-5-yl)-[1,3,4]oxadiazoles 8, 10 and 2-(thiazol-5-yl)-[1,3,4] thiadiazoles 9, 11 were obtained.
引用
收藏
页码：121 / 124
页数：4
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