Translactional research in ophthalmology: the path to personalized medicine

被引:0
作者
Siqueira, Rubens Camargo [1 ,2 ]
机构
[1] CPRS, Sao Jose Do Rio Preto, SP, Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil
关键词
Translational research; Stem cell; Gene therapy; Biomedical research; RETINAL DEGENERATION; GENE-THERAPY; CELL; DISEASE; SUSCEPTIBILITY; MECHANISMS; VISION; RESCUE; RISK;
D O I
10.1590/S0034-72802012000500015
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Scientific research is traditionally divided into two categories: basic research and applied research. Basic research is needed to provide a better understanding of disease, but not directly translating that knowledge into useful clinical application. Translational research would be the advancement of science applied to the development of new diagnostic tests, drugs and or intervention techniques for patients with established understanding of disease development and progression. The main goal of translational research is to integrate advances in biotechnology, clinical trials, boosting the research bench to the bedside. The evolution of translational research in the area of ophthalmology are building a medicine of greater effectiveness in the prevention and treatment individualized form the basic ingredients of the desired personalized medicine. This paper describes the basic concepts of translational research and its application in ophthalmology.
引用
收藏
页码:338 / 342
页数:5
相关论文
共 35 条
[1]   Gene therapy restores vision in a canine model of childhood blindness [J].
Acland, GM ;
Aguirre, GD ;
Ray, J ;
Zhang, Q ;
Aleman, TS ;
Cideciyan, AV ;
Pearce-Kelling, SE ;
Anand, V ;
Zeng, Y ;
Maguire, AM ;
Jacobson, SG ;
Hauswirth, WW ;
Bennett, J .
NATURE GENETICS, 2001, 28 (01) :92-95
[2]  
[Anonymous], CONSCIENTIAE SAUDE
[3]  
Awh CC, 2011, RETINA TODAY, P78
[4]   Effect of gene therapy on visual function in Leber's congenital amaurosis [J].
Bainbridge, James W. B. ;
Smith, Alexander J. ;
Barker, Susie S. ;
Robbie, Scott ;
Henderson, Robert ;
Balaggan, Kamaljit ;
Viswanathan, Ananth ;
Holder, Graham E. ;
Stockman, Andrew ;
Tyler, Nick ;
Petersen-Jones, Simon ;
Bhattacharya, Shomi S. ;
Thrasher, Adrian J. ;
Fitzke, Fred W. ;
Carter, Barrie J. ;
Rubin, Gary S. ;
Moore, Anthony T. ;
Ali, Robin R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (21) :2231-2239
[5]  
Boatright JH, 2006, MOL VIS, V12, P1706
[6]   Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration [J].
Chen, Wei ;
Stambolian, Dwight ;
Edwards, Albert O. ;
Branham, Kari E. ;
Othman, Mohammad ;
Jakobsdottir, Johanna ;
Tosakulwong, Nirubol ;
Pericak-Vance, Margaret A. ;
Campochiaro, Peter A. ;
Klein, Michael L. ;
Tan, Perciliz L. ;
Conley, Yvette P. ;
Kanda, Atsuhiro ;
Kopplin, Laura ;
Li, Yanming ;
Augustaitis, Katherine J. ;
Karoukis, Athanasios J. ;
Scott, William K. ;
Agarwal, Anita ;
Kovach, Jaclyn L. ;
Schwartz, Stephen G. ;
Postel, Eric A. ;
Brooks, Matthew ;
Baratz, Keith H. ;
Brown, William L. ;
Brucker, Alexander J. ;
Orlin, Anton ;
Brown, Gary ;
Ho, Allen ;
Regillo, Carl ;
Donoso, Larry ;
Tian, Lifeng ;
Kaderli, Brian ;
Hadley, Dexter ;
Hagstrom, Stephanie A. ;
Peachey, Neal S. ;
Klein, Ronald ;
Klein, Barbara E. K. ;
Gotoh, Norimoto ;
Yamashiro, Kenji ;
Ferris, Frederick, III ;
Fagerness, Jesen A. ;
Reynolds, Robyn ;
Farrer, Lindsay A. ;
Kim, Ivana K. ;
Miller, Joan W. ;
Corton, Marta ;
Carracedo, Angel ;
Sanchez-Salorio, Manuel ;
Pugh, Elizabeth W. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7401-7406
[7]   ABCA4 disease progression and a proposed strategy for gene therapy [J].
Cideciyan, Artur V. ;
Swider, Malgorzata ;
Aleman, Tomas S. ;
Tsybovsky, Yaroslav ;
Schwartz, Sharon B. ;
Windsor, Elizabeth A. M. ;
Roman, Alejandro J. ;
Sumaroka, Alexander ;
Steinberg, Janet D. ;
Jacobson, Samuel G. ;
Stone, Edwin M. ;
Palczewski, Krzysztof .
HUMAN MOLECULAR GENETICS, 2009, 18 (05) :931-941
[8]   Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve [J].
Dahlmann-Noor, Annegret ;
Vijay, Sauparnika ;
Jayaram, Hari ;
Limb, Astrid ;
Khaw, Peng Tee .
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2010, 45 (04) :333-341
[9]   Personalized medicine: The future is not what it used to be [J].
Demeure, Michael J. .
SURGERY, 2009, 146 (06) :971-978
[10]   Lighting a candle in the dark advances in genetics and gene therapy of recessive retinal dystrophies (vol 120, pg 3042, 2010) [J].
den Hollander, Anneke I. ;
Black, Aaron ;
Bennett, Jean ;
Cremers, Frans P. M. .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (01) :456-457