Intrinsically Mn2+-Chelated Polydopamine Nanoparticles for Simultaneous Magnetic Resonance Imaging and Photothermal Ablation of Cancer Cells

被引：155
作者：
Miao, Zhao-Hua [2 ,3 ]
Wang, Hui [4 ]
Yang, Huanjie [4 ]
Li, Zheng-Lin [5 ]
Zhen, Liang [2 ,3 ]
Xu, Cheng-Yan [1 ,2 ,3 ]
机构：
[1] Harbin Inst Technol, Sch Mat Sci & Engn, Harbin 150001, Peoples R China
[2] Harbin Inst Technol, Sch Mat Sci & Engn, Harbin 150001, Peoples R China
[3] Harbin Inst Technol, TMOE Key Lab Microsyst & Microstruct Mfg, Harbin 150080, Peoples R China
[4] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
[5] Harbin Inst Technol, Sch Sci, Condensed Matter Sci & Technol Inst, Harbin 150000, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 31期
关键词：
polydopamine nanoparticles; theranostic agent; photothermal ablation; magnetic resonance imaging; cancer cells; PRUSSIAN BLUE NANOPARTICLES; IN-VIVO; HEPATOCELLULAR-CARCINOMA; CONTRAST AGENTS; THERAPY; GADOLINIUM; MRI; MANGANESE; NANOSPHERES; RELAXIVITY;
D O I：
10.1021/acsami.5b06265
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Theranostic agents for magnetic resonance imaging (MRI) guided photothermal therapy have attracted intensive interest in cancer diagnosis and treatment. However, the development of biocompatible theranostic agents with high photothermal conversion efficiency and good MRI contrast effect remains a challenge. Herein, PEGylated Mn2+-chelated polydopamine (PMPDA) nano-particles were successfully developed as novel theranostic agents for simultaneous MRI signal enhancement and photothermal ablation of cancer cells, based on intrinsic manganese-chelating properties and strong near-infrared absorption of polydopamine nanomaterials. The obtained PMPDA nanoparticles showed significant MET signal enhancement for both in vitro and in vivo imaging. Highly effective photothermal ablation of He La cells exposed to PMPDA nanoparticles was then achieved upon laser irradiation for 10 min. Furthermore, the excellent biocompatibility of PMPDA nanoparticles, because of the use of Mn2+ ions as diagnostic agents and biocompatible polydopamine as photothermal agents, was confirmed by a standard MTT assay. Therefore, the developed PMPDA nanoparticles could be used as a promising theranostic agent for MRI-guided photothermal therapy of cancer cells.
引用
收藏
页码：16946 / 16952
页数：7
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