A High Burden Human Immunodeficiency Virus and Tuberculosis Resource Limited Setting, Gains from Including Xpert MTB/RIF in the Diagnostic Algorithm of Fluid Specimens Submitted for Exclusion of Lymphoma by Immunophenotypic Analysis

被引：5

作者：

Kilfoil, Kim Michelle ^{[1
]}

Mayne, Elizabeth ^{[1
]}

Scott, Lesley ^{[1
,2
]}

Stevens, Wendy ^{[1
,2
]}

机构：

[1] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Dept Mol Med & Haematol, Johannesburg, South Africa

[2] Natl Hlth Lab Serv, Natl Prior Program, Johannesburg, South Africa

来源：

PLOS ONE | 2015年 / 10卷 / 08期

关键词：

MYCOBACTERIUM-TUBERCULOSIS; EXTRAPULMONARY TUBERCULOSIS; RIFAMPIN RESISTANCE; NONRESPIRATORY SPECIMENS; RAPID DIAGNOSIS; ASSAY; METAANALYSIS; SAMPLES;

D O I：

10.1371/journal.pone.0134404

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study investigated the benefit of incorporating Xpert MTB/RIF into the diagnostic algorithm of fluid specimens received for immunophenotypic analysis to exclude lymphoma. It was found that in a high burden HIV/TB setting, like South Africa, 130/229 (57%) of fluid specimens referred for immunophenotypic analysis to exclude lymphoma are not referred for concurrent MTBC liquid culture testing by the treating clinician. Of 99/229 (43%) specimens with corresponding culture results, Xpert sensitivity and specificity were 50% (CI: 26-75%) and 99% (CI: 91-100%) respectively. This demonstrates that incorporation of Xpert into the laboratory diagnostic algorithm in the immunophenotypic laboratory would improve patient work-up and care.

引用

页数：5

共 28 条

[1]

[Anonymous], WHO GLOB TUB REP 201

[2]

[Anonymous], WHO TUB COUNTR PROF

[3] Comparison of the Xpert MTB/RIF Test with an IS6110-TaqMan Real-Time PCR Assay for Direct Detection of Mycobacterium tuberculosis in Respiratory and Nonrespiratory Specimens [J].