Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

被引：74

作者：

Gross, Catharina C. ^{[1
]}

Schulte-Mecklenbeck, Andreas ^{[1
]}

Wiendl, Heinz ^{[1
]}

Marcenaro, Emanuela ^{[2
,3
]}

de Rosbo, Nicole Kerlero ^{[4
]}

Uccelli, Antonio ^{[2
,4
,5
]}

Laroni, Alice ^{[2
,4
,5
]}

机构：

[1] Univ Hosp Munster, Dept Neurol, Munster, Germany

[2] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

[3] Univ Genoa, Dept Expt Med, Genoa, Italy

[4] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[5] IRCCS San Martino IST, Genoa, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2016年 / 7卷

关键词：

natural killer cells; CD56(bright) NK cells; CD56(dim) NK cells; regulatory immune cells; innate immune system; multiple sclerosis; HUMAN NK-CELLS; SECONDARY LYMPHOID ORGANS; CONTROLLED PHASE-3 TRIAL; ORAL FINGOLIMOD FTY720; SOLUBLE HLA-E; DENDRITIC-CELLS; T-CELLS; SPHINGOSINE-1-PHOSPHATE RECEPTOR; CEREBROSPINAL-FLUID; AFFERENT LYMPH;

D O I：

10.3389/fimmu.2016.00606

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is increasing evidence that natural killer (NK) cells exhibit regulatory features. Among them, CD56(bright) NK cells have been suggested to play a major role in controlling T cell responses and maintaining homeostasis. Dysfunction in NK cell-mediated regulatory features has been recently described in untreated multiple sclerosis (MS), suggesting a contribution to MS pathogenesis. Moreover, biological disease-modifying treatments effective in MS apparently enhance the frequencies and/or regulatory function of NK cells, further pointing toward an immunoprotective role of NK cells in MS. Here, we summarize the current knowledge on the regulatory functions of NK cells, based on their interactions with other cells belonging to the innate compartment, as well as with adaptive effector cells. We review the more recent data reporting disruption of NK cell/T cell interactions in MS and discuss how disease-modifying treatments for MS affect NK cells.

引用

页数：8