Bio-mediated synthesis of copper oxide nanoparticles using Pogestemon benghalensis extract for treatment of the esophageal cancer in nursing care

被引：5

作者：

Zou, Xiaoying ^{[1
]}

Cheng, Shiwei ^{[1
]}

You, Bo ^{[1
]}

Yang, Changting ^{[1
]}

机构：

[1] China Med Univ, Canc Hosp, Dept Thorac Surg, Liaoning Canc Hosp & Inst, 44 Xiaoheyan Rd, Shenyang 110042, Liaoning, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2020年 / 58卷

关键词：

CuO NPs; Esophageal cancer; Cytotoxicity; REDUCED GRAPHENE OXIDE; GREEN SYNTHESIS; SILVER NANOPARTICLES; CUO NANOPARTICLES; ANTICANCER ACTIVITY; EPITHELIAL-CELLS; TOXICITY; METAL; BIOSYNTHESIS; CYTOTOXICITY;

D O I：

10.1016/j.jddst.2020.101759

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Copper oxide nanoparticles (CuO NPs) were fabricated by employing an easy and bio-synthetic approach utilizing peel extract of Pogestemon benghalensis (P. benghalensis) at ambient temperature. The bio-fabricated CuO NPs were studied using X-ray diffraction (X-RD), Ultra Violet-Visible absorption (UV-Vis) spectroscopy, Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR) characterization techniques. Biosynthesized nanoparticles are crystalline in nature having 40 nm mean size of the particle. Also, the prepared NPs were studied for their cytotoxicity towards KYSE30 human esophageal cancer (EAC) cell line and the outcomes of this study displayed that CuO NPs had antineoplastic activity with 13.96 mg/L of half maximal inhibitory concentration (IC50), whereas no higher effects of cytotoxicity were noticed in Human Dermal Fibroblasts (HDF) with 48.88 mg/L of IC50 value. Further, the obtained NPs can be used for the development of novel drugs that can be used for the treatment of esophageal cancer in nursing care.

引用

页数：7

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