Tumor-Associated Antigens in Breast Cancer

被引：53

作者：

Criscitiello, Carmen ^{[1
]}

机构：

[1] European Inst Oncol, Milan, Italy

来源：

BREAST CARE | 2012年 / 7卷 / 04期

关键词：

Breast cancer; Tumor antigen; Vaccine; COLONY-STIMULATING FACTOR; SYNTHETIC MUC1 PEPTIDE; HIGH-DOSE CHEMOTHERAPY; STEM-CELL RESCUE; WILMS-TUMOR; IMMUNE-RESPONSES; GENE WT1; SUPPRESSOR WT1; CARCINOEMBRYONIC ANTIGEN; DENDRITIC CELLS;

D O I：

10.1159/000342164

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The targets for the immune system are antigens present on cancer cells; however, many are not cancer-specific and may also be found on normal tissues. These antigens are often products of mutated cellular genes, aberrantly expressed normal genes, or genes encoding viral proteins. Vaccines constitute an active and specific immunotherapy designed to stimulate the intrinsic antitumor immune response by presenting tumor-associated antigens expressed on normal tissues that are over-expressed on tumor cells.

引用

页码：262 / 266

页数：5

共 54 条

[1]

Aarts WM, 2002, CANCER RES, V62, P5770

[2] VACCINIA VIRUS MUC1 IMMUNIZATION OF MICE - IMMUNE-RESPONSE AND PROTECTION AGAINST THE GROWTH OF MURINE TUMORS BEARING THE MUC1 ANTIGEN [J].