Atheroprotective effects of conjugated linoleic acid

被引:71
作者
Bruen, Robyn [1 ]
Fitzsimons, Stephen [1 ]
Belton, Orina [1 ]
机构
[1] Univ Coll Dublin, UCD Conway Inst, Sch Biomol & Biomed Sci, Dublin 4, Ireland
关键词
atherosclerosis; conjugated linoleic acid; inflammation; resolution; CARDIOVASCULAR RISK-FACTORS; OXIDE SYNTHASE EXPRESSION; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; BODY-FAT MASS; PPAR-GAMMA; GENE-EXPRESSION; INSULIN SENSITIVITY; ATHEROSCLEROTIC PLAQUES; MACROPHAGE ACTIVATION;
D O I
10.1111/bcp.12948
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Atherosclerosis, the underlying cause of heart attack and strokes, is a progressive dyslipidaemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atherosclerosis have been identified, there is limited information on those governing regression. Conjugated linoleic acid (CLA) is a generic term denoting a group of naturally occurring isomers of linoleic acid (18: 2, n6) that differ in the position or geometry (i.e. cis or trans) of their double bonds. The most predominant isomers in ruminant fats are cis-9, trans-11 CLA (c9, t11-CLA), which accounts for more than 80% of CLA isomers in dairy products and trans-10, cis-12 CLA (t10, c12-CLA). Dietary administration of a blend of the two most abundant isomers of CLA has been shown to inhibit the progression and induce the regression of preestablished atherosclerosis. Studies investigating the mechanisms involved in CLA-induced atheroprotective effects are continually emerging. The purpose of this review is to discuss comprehensively the effects of CLA on monocyte/macrophage function in atherosclerosis and to identify possible mechanisms through which CLA mediates its atheroprotective effects.
引用
收藏
页码:46 / 53
页数:8
相关论文
共 98 条
[1]   Phenotypic modulation of macrophages in response to plaque lipids [J].
Adamson, Samantha ;
Leitinger, Norbert .
CURRENT OPINION IN LIPIDOLOGY, 2011, 22 (05) :335-342
[2]  
Al-Mamari Ali, 2009, Oman Med J, V24, P173, DOI 10.5001/omj.2009.34
[3]   The pathophysiology of cigarette C-V smoking and cardiovascular disease - An update [J].
Ambrose, JA ;
Barua, RS .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (10) :1731-1737
[4]   Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice [J].
Arbones-Mainar, Jose M. ;
Navarro, Maria A. ;
Guzman, Mario A. ;
Arnal, Carmen ;
Surra, Joaquin C. ;
Acin, Sergio ;
Carnicer, Ricardo ;
Osada, Jesus ;
Roche, Helen M. .
ATHEROSCLEROSIS, 2006, 189 (02) :318-327
[5]   Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease [J].
Bassaganya-Riera, J ;
Reynolds, K ;
Martino-Catt, S ;
Cui, YZ ;
Hennighausen, L ;
Gonzalez, F ;
Rohrer, J ;
Benninghoff, AU ;
Hontecillas, R .
GASTROENTEROLOGY, 2004, 127 (03) :777-791
[6]   CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD [J].
Bassaganya-Riera, Josep ;
Hontecillas, Raquel .
CLINICAL NUTRITION, 2006, 25 (03) :454-465
[7]   MONOCYTE ADHERENCE TO HUMAN VASCULAR ENDOTHELIUM [J].
BEEKHUIZEN, H ;
VANFURTH, R .
JOURNAL OF LEUKOCYTE BIOLOGY, 1993, 54 (04) :363-378
[8]   Conjugated linoleic acid reduces body fat mass in overweight and obese humans [J].
Blankson, H ;
Stakkestad, JA ;
Fagertun, H ;
Thom, E ;
Wadstein, J ;
Gudmundsen, O .
JOURNAL OF NUTRITION, 2000, 130 (12) :2943-2948
[9]   PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].
Bouhlel, M. Amine ;
Derudas, Bruno ;
Rigamonti, Elena ;
Dievart, Rebecca ;
Brozek, John ;
Haulon, Stephan ;
Zawadzki, Christophe ;
Jude, Brigitte ;
Torpier, Gerard ;
Marx, Nikolaus ;
Staels, Bart ;
Chinetti-Gbaguidi, Giulia .
CELL METABOLISM, 2007, 6 (02) :137-143
[10]   Dectin-1 is a major β-glucan receptor on macrophages [J].
Brown, GD ;
Taylor, PR ;
Reid, DM ;
Willment, JA ;
Williams, DL ;
Martinez-Pomares, L ;
Wong, SYC ;
Gordon, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) :407-412