Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes

被引：20

作者：

Lee, Heejin ^{[1
]}

Lee, Jae Kyun ^{[2
]}

Min, Sun-Joon ^{[3
]}

Seo, Hyeonglim ^{[1
]}

Lee, Youngbok ^{[1
,3
]}

Rhee, Hakjune ^{[1
,3
]}

机构：

[1] Hanyang Univ, Dept Bionanotechnol, Hanyang Daehak Ro 55, Ansan 15588, Gyeonggi Do, South Korea

[2] Korea Inst Sci & Technol, Ctr Neuromed, Hwarangro 14 Gil 5, Seoul 136791, South Korea

[3] Hanyang Univ, Dept Appl Chem, Hanyang Daehak Ro 55, Ansan 15588, Gyeonggi Do, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 08期

关键词：

ONE-POT SYNTHESIS; CLICK CHEMISTRY; ROOM-TEMPERATURE; SULFONYL AZIDES; ANTI-3-ARYL-2,3-DIBROMOPROPANOIC ACIDS; MEDICINAL CHEMISTRY; ORGANIC AZIDES; SODIUM-AZIDE; SOLID-PHASE; CYCLOADDITION;

D O I：

10.1021/acs.joc.8b00022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper(I)-catalyzed azide-alkyne cycloaddition reaction has been extensively studied and widely applied in organic synthesis. However, the formation of 1,2,3-triazoles with electron-deficient azide has been a challenging problem. In this report, we have demonstrated the formation of regioselective 1,4-disubstituted 1,2,3-triazoles from various types of aryl terminal alkynes and azidoformates, which are electron-deficient azides, using a commercialized [Cu-(CH3CN)(4)]PF6 copper(I) catalyst under mild conditions.

引用

页码：4805 / 4811

页数：7

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