The Norbornene Shuttle: Multicomponent Domino Synthesis of Tetrasubstituted Helical Alkenes through Multiple C-H Functionalization

被引：123

作者：

Gericke, Kersten M. ^{[1
]}

Chai, David I. ^{[1
]}

Bieler, Nikolas ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Chem Labs, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H activation; domino reactions; multicomponent reactions; palladium; strained molecules; ALKYLATION-ALKENYLATION REACTIONS; PALLADIUM-CATALYZED ALKYLATION; HETEROCYCLES; SEQUENCE; INDOLES; ROUTE;

D O I：

10.1002/anie.200805512

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Shall we dance? Within the proposed mechanism for the palladium-catalyzed title reaction, the strained alkene norbornene (or norbornadiene) enters and exits the catalytic cycle in a catalytic "square dabce", acting as both a promoter and a coupling partner in the formation of four carbon-carbon bonds, two of them by challenging C - H activation processes. © 2009 Wiley-VCH Verleg GmbH & Co. KGaA.

引用

页码：1447 / 1451

页数：5

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