GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations

被引：18

作者：

Perugini, M. ^{[1
,3
,4
]}

Iarossi, D. G. ^{[1
,2
]}

Kok, C. H. ^{[1
,3
,4
]}

Cummings, N. ^{[5
,6
]}

Diakiw, S. M. ^{[1
]}

Brown, A. L. ^{[1
,7
,8
]}

Danner, S. ^{[2
]}

Bardy, P. ^{[9
,10
]}

To, L. Bik ^{[1
,2
,3
,4
]}

Wei, A. H. ^{[5
,6
]}

Lewis, I. D. ^{[1
,2
,3
,4
]}

D'Andrea, R. J. ^{[1
,3
,4
,7
,8
,9
,10
]}

机构：

[1] SA Pathol, Dept Haematol, Ctr Canc Biol, Adelaide, SA, Australia

[2] Royal Adelaide Hosp, Dept Haematol, Adelaide, SA 5000, Australia

[3] Univ Adelaide, Ctr Personalised Canc Med, Adelaide, SA, Australia

[4] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[5] Alfred Hosp, Dept Clin Haematol, Adelaide, SA, Australia

[6] Monash Univ, Adelaide, SA, Australia

[7] Univ Adelaide, Sch Mol Sci, Adelaide, SA, Australia

[8] Univ Adelaide, Sch Biomed Sci, Adelaide, SA, Australia

[9] Queen Elizabeth Hosp, Dept Haematol & Oncol, Adelaide, SA, Australia

[10] Queen Elizabeth Hosp, Basil Hetzel Inst Translat Hlth Res, Adelaide, SA, Australia

来源：

LEUKEMIA | 2013年 / 27卷 / 07期

关键词：

OLDER PATIENTS; DECITABINE; CHEMOTHERAPY; GENE;

D O I：

10.1038/leu.2012.346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1588 / 1592

页数：6

共 16 条

[1] Decitabine-induced demethylation of 5′ CpG island in GADD45A leads to apoptosis in osteosarcoma cells [J].

Al-Romaih, Khaldoun ;

Sadikovic, Bekim ;

Yoshimoto, Maisa ;

Wang, Yuzhuo ;

Zielenska, Maria ;

Squire, Jeremy A. .

NEOPLASIA, 2008, 10 (05) :471-480

[2] Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation [J].

Barreto, Guillermo ;

Schaefer, Andrea ;

Marhold, Joachim ;

Stach, Dirk ;

Swaminathan, Suresh K. ;

Handa, Vikas ;

Doederlein, Gabi ;

Maltry, Nicole ;

Wu, Wei ;

Lyko, Frank ;

Niehrs, Christof .

NATURE, 2007, 445 (7128) :671-675

[3] Multicenter, Phase II Study of Decitabine for the First-Line Treatment of Older Patients With Acute Myeloid Leukemia [J].

Cashen, Amanda F. ;

Schiller, Gary J. ;

O'Donnell, Margaret R. ;

DiPersio, John F. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (04) :556-561

[4] Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation [J].

Figueroa, Maria E. ;

Abdel-Wahab, Omar ;

Lu, Chao ;

Ward, Patrick S. ;

Patel, Jay ;

Shih, Alan ;

Li, Yushan ;

Bhagwat, Neha ;

Vasanthakumar, Aparna ;

Fernandez, Hugo F. ;

Tallman, Martin S. ;

Sun, Zhuoxin ;

Wolniak, Kristy ;

Peeters, Justine K. ;

Liu, Wei ;

Choe, Sung E. ;

Fantin, Valeria R. ;

Paietta, Elisabeth ;

Lowenberg, Bob ;

Licht, Jonathan D. ;

Godley, Lucy A. ;

Delwel, Ruud ;

Valk, Peter J. M. ;

Thompson, Craig B. ;

Levine, Ross L. ;

Melnick, An .

CANCER CELL, 2010, 18 (06) :553-567

[5] Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials [J].

Grimwade, David ;

Hills, Robert K. ;

Moorman, Anthony V. ;

Walker, Helen ;

Chatters, Stephen ;

Goldstone, Anthony H. ;

Wheatley, Keith ;

Harrison, Christine J. ;

Burnett, Alan K. .

BLOOD, 2010, 116 (03) :354-365

[6]

Liebermann Dan A., 2011, Critical Reviews in Oncogenesis, V16, P129

[7] TET2 Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study [J].

Metzeler, Klaus H. ;

Maharry, Kati ;

Radmacher, Michael D. ;

Mrozek, Krzysztof ;

Margeson, Dean ;

Becker, Heiko ;

Curfman, John ;

Holland, Kelsi B. ;

Schwind, Sebastian ;

Whitman, Susan P. ;

Wu, Yue-Zhong ;

Blum, William ;

Powell, Bayard L. ;

Carter, Thomas H. ;

Wetzler, Meir ;

Moore, Joseph O. ;

Kolitz, Jonathan E. ;

Baer, Maria R. ;

Carroll, Andrew J. ;

Larson, Richard A. ;

Caligiuri, Michael A. ;

Marcucci, Guido ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (10) :1373-1381

[8] Repression of Gadd45α by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation [J].

Perugini, M. ;

Kok, C. H. ;

Brown, A. L. ;

Wilkinson, C. R. ;

Salerno, D. G. ;

Young, S. M. ;

Diakiw, S. M. ;

Lewis, I. D. ;

Gonda, T. J. ;

D'Andrea, R. J. .

LEUKEMIA, 2009, 23 (04) :729-738

[9] Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia [J].

Quintas-Cardama, Alfonso ;

Ravandi, Farhad ;

Liu-Dumlao, Theresa ;

Brandt, Mark ;

Faderl, Stefan ;

Pierce, Sherry ;

Borthakur, Gautam ;

Garcia-Manero, Guillermo ;

Cortes, Jorge ;

Kantarjian, Hagop .

BLOOD, 2012, 120 (24) :4840-4845

[10] Methylation-Mediated Repression of GADD45α in Prostate Cancer and Its Role as a Potential Therapeutic Target [J].

Ramachandran, Kavitha ;

Gopisetty, Gopal ;

Gordian, Edna ;

Navarro, Loida ;

Hader, Christiane ;

Reis, Isildinha M. ;

Schulz, Wolfgang A. ;

Singal, Rakesh .

CANCER RESEARCH, 2009, 69 (04) :1527-1535

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