A Biobank of Colorectal Cancer Patient-Derived Xenografts

被引：13

作者：

Abdirahman, Suad M. ^{[1
,2
]}

Christie, Michael ^{[1
,3
]}

Preaudet, Adele ^{[1
]}

Burstroem, Marie C. U. ^{[1
]}

Mouradov, Dmitri ^{[1
,2
]}

Lee, Belinda ^{[1
]}

Sieber, Oliver M. ^{[1
,2
,4
,5
]}

Putoczki, Tracy L. ^{[1
,2
,4
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Personalised Oncol Div, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Dept Surg, Parkville, Vic 3010, Australia

[5] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CANCERS | 2020年 / 12卷 / 09期

基金：

英国医学研究理事会;

关键词：

colon cancer; chemotherapy; model; patient-derived; xenograft; EPITHELIAL OVARIAN-CANCER; COLON-CANCER; TUMOR XENOGRAFTS; CELL-LINE; 1ST-LINE TREATMENT; STAGE-II; MODELS; ESTABLISHMENT; IDENTIFICATION; HETEROGENEITY;

D O I：

10.3390/cancers12092340

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly for late-stage disease. Patient-derived xenografts (PDXs) have emerged as an informative, renewable experimental resource to model CRC architecture and biology. Here, we describe the generation of a biobank of CRC PDXs from stage I to stage IV patients. We demonstrate that PDXs within our biobank recapitulate the histopathological and mutation features of the original patient tumor. In addition, we demonstrate the utility of this resource in pre-clinical chemotherapy and targeted treatment studies, highlighting the translational potential of PDX models in the identification of new therapies that will improve the overall survival of CRC patients.

引用

页码：1 / 19

页数：19

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