Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

被引：5
作者：
Thanh Thi Ngoc Nguyen [1 ,2 ]
Minh Thi Hong Tran [1 ,2 ]
Vy Thi Lan Nguyen [1 ,2 ]
Uyen Doan Phuong Nguyen [1 ,2 ]
Giang Dien Thanh Nguyen [1 ,2 ]
Luan Huu Huynh [1 ,2 ]
Hue Thi Nguyen [1 ,2 ]
机构：
[1] Univ Sci, Fac Biol & Biotechnol, Dept Physiol & Anim Biotechnol, Ho Chi Minh City, Vietnam
[2] Vietnam Natl Univ, Ho Chi Minh City, Vietnam
来源：
TURKISH JOURNAL OF BIOLOGY | 2020年 / 44卷 / 05期
关键词：
Breast cancer; microRNA; miRNA; single nucleotide polymorphism; SNP; DNA-DAMAGE RESPONSE; GENETIC VARIANT; FEEDBACK LOOP; MIRNA GENES; ASSOCIATION; RISK; SUSCEPTIBILITY; RECOGNITION; MIR-423; MIR-605;
D O I：
10.3906/biy-2004-78
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.
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收藏
页码：284 / 294
页数：11
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