One-Pot Copper-Catalyzed Three-Component Synthesis of Quinoxalines by Condensation and C-N Bond Formation

被引：14

作者：

Yuan, Hua ^{[1
,2
]}

Li, Kangning ^{[1
,2
]}

Chen, Yongxin ^{[1
,2
]}

Wang, Yu ^{[1
,2
]}

Cui, Jiaojiao ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

来源：

SYNLETT | 2013年 / 24卷 / 17期

基金：

中国国家自然科学基金;

关键词：

quinoxalines; arylacetaldehydes; sodium azide; three-component reaction; O-PHENYLENEDIAMINES; MOLECULAR-IODINE; DERIVATIVES; INHIBITORS; WATER;

D O I：

10.1055/s-0033-1339797

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel way of synthesizing quinoxalines has been developed that involves condensation and C-N bond formation in a copper-catalyzed, one-pot, three-component reaction. The reaction was optimized when 2-iodoanilines (1.0 equiv), arylacetaldehydes (2.0 equiv), sodium azide (1.2 equiv), CuI (10mol%), DMEDA (10mol%), and K2CO3 (1.0 equiv) were reacted in DMSO at 80 degrees C for 20hours. This approach was used to directly synthesize a variety of quinoxalines in moderate to good yields.

引用

页码：2315 / 2319

页数：5

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