Radical reactions of aryl alkynoates in organic synthesis: Recent advances

被引：30

作者：

Ni, Shengyang ^{[1
]}

Zhou, Jie ^{[2
]}

Mei, Haibo ^{[1
]}

Han, Jianlin ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Aryl alkynoates; Cyclization; Migration; Difunctionalization; Decarboxylation; METAL-FREE CONDITIONS; FRIEDEL-CRAFTS ALKENYLATION; CROSS-COUPLING REACTIONS; C BOND FORMATIONS; ACTIVATED ALKYNES; OXIDATIVE DIFUNCTIONALIZATION; DEAROMATIVE SPIROCYCLIZATION; MEDICINAL CHEMISTRY; BIOLOGICAL-ACTIVITY; CASCADE REACTION;

D O I：

10.1016/j.tetlet.2018.02.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aryl alkynoate is an important intermediate and powerful synthetic tool in organic chemistry, because it contains acetylene bond which can be easily introduced of different functional groups. During the past decades, several types of reactions and coupling partners have been developed for the functionalization of aryl alkynoates. In this review, we summarize the recent advances on the reactions of aryl alkynoates, including direct cyclization, ester group migration/cyclization, aryl migration/decarboxylation, ipsocyclization/clearomatization, and other reactions in the past decade. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1309 / 1316

页数：8

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