Synthesis, cytotoxic, and DNA binding studies of novel fluorinated condensed pyrano pyrazoles

被引：55

作者：

Bhavanarushi, S. ^{[1
]}

Kanakaiah, V. ^{[1
]}

Yakaiah, E. ^{[1
]}

Saddanapu, V. ^{[2
]}

Addlagatta, A. ^{[2
]}

Rani, J. Vatsala ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Fluoro Organ Div, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500607, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 05期

关键词：

DBU; Knoevenagel condensation; Pyrano[2,3-c]pyrazole; HeLa cells; Electrochemical; Intercalation; ONE-POT SYNTHESIS; MICROWAVE IRRADIATION; CONVENIENT SYNTHESIS; MINOR-GROOVE; CELL-LINES; DERIVATIVES; AGENTS;

D O I：

10.1007/s00044-012-0239-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One pot solvent-free synthetic method is developed for the synthesis of novel pyrano[2,3-c]pyrazole analogs. Cytotoxicity experiments conducted against a pair of cancerous, non-cancerous lung cell lines, and a cervical cell line is described. These compounds are selectively toxic against cancer cells and not normal cells. Molecular mechanism is established for the mode of DNA binding of these compounds using electrochemical and proton NMR methods.

引用

页码：2446 / 2454

页数：9

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