Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

被引：155

作者：

Brunskill, Eric W. ^{[1
]}

Aronow, Bruce J. ^{[2
]}

Georgas, Kylie ^{[3
]}

Rumballe, Bree ^{[3
]}

Valerius, M. Todd ^{[4
]}

Aronow, Jeremy ^{[2
]}

Kaimal, Vivek ^{[2
]}

Jegga, Anil G. ^{[2
]}

Grimmond, Sean ^{[3
]}

McMahon, Andrew P. ^{[4
]}

Patterson, Larry T. ^{[5
]}

Little, Melissa H. ^{[3
]}

Potter, S. Steven ^{[1
]}

机构：

[1] Childrens Hosp, Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA

[2] Childrens Hosp, Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA

[3] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[4] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[5] Childrens Hosp, Med Ctr, Div Nephrol, Cincinnati, OH 45229 USA

来源：

DEVELOPMENTAL CELL | 2008年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.devcel.2008.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Kidney development is based on differential cell-type-specific expression of a vast number of genes. While multiple critical genes and pathways have been elucidated, a genome-wide analysis of gene expression within individual cellular and anatomic structures is lacking. Accomplishing this could provide significant new insights into fundamental developmental mechanisms such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmentation. We describe here a comprehensive gene expression atlas of the developing mouse kidney based on the isolation of each major compartment by either laser capture microdissection or fluorescence-activated cell sorting, followed by microarray profiling. The resulting data agree with known expression patterns and additional in situ hybridizations. This kidney atlas allows a comprehensive analysis of the progression of gene expression states during nephrogenesis, as well as discovery of potential growth factor-receptor interactions. In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development.

引用

页码：781 / 791

页数：11

共 34 条

[1] Tmem27:: A cleaved and shed plasma membrane protein that stimulates pancreatic β cell proliferation [J].

Akpinar, P ;

Kuwajima, S ;

Krützfeldt, J ;

Stoffel, M .

CELL METABOLISM, 2005, 2 (06) :385-397

[2] Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to Forkhead box O-mediated transcription [J].

Almeida, Maria ;

Han, Li ;

Martin-Millan, Marta ;

O'Brien, Charles A. ;

Manolagas, Stavros C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27298-27305

[3] A VARIANT NUCLEAR-PROTEIN IN DEDIFFERENTIATED HEPATOMA-CELLS BINDS TO THE SAME FUNCTIONAL SEQUENCES IN THE BETA-FIBRINOGEN GENE PROMOTER AS HNF-1 [J].

BAUMHUETER, S ;

COURTOIS, G ;

CRABTREE, GR .

EMBO JOURNAL, 1988, 7 (08) :2485-2493

[4] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[5] Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia [J].

Boyle, Scott ;

Misfeldt, Andrew ;

Chandler, Kelly J. ;

Deal, Karen K. ;

Southard-Smith, E. Michelle ;

Mortlock, Douglas P. ;

Baldwin, H. Scott ;

de Caestecker, Mark .

DEVELOPMENTAL BIOLOGY, 2008, 313 (01) :234-245

[6] Liver-enriched transcription factors and hepatocyte differentiation [J].

Cereghini, S .

FASEB JOURNAL, 1996, 10 (02) :267-282

[7] Temporal and spatial transcriptional programs in murine kidney development [J].

Challen, G ;

Gardiner, B ;

Caruana, G ;

Kostoulias, X ;

Martinez, G ;

Crowe, M ;

Taylor, DF ;

Bertram, J ;

Little, M ;

Grimmond, SM .

PHYSIOLOGICAL GENOMICS, 2005, 23 (02) :159-171

[8] Improved human disease candidate gene prioritization using mouse phenotype [J].

Chen, Jing ;

Xu, Huan ;

Aronow, Bruce J. ;

Jegga, Anil G. .

BMC BIOINFORMATICS, 2007, 8 (1)

[9] The cellular basis of kidney development [J].

Dressler, Gregory R. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :509-529

[10] Functional interaction between β-catenin and FOXO in oxidative stress signaling [J].

Essers, MAG ;

de Vries-Smits, LMM ;

Barker, N ;

Polderman, PE ;

Burgering, BMT ;

Korswagen, HC .

SCIENCE, 2005, 308 (5725) :1181-1184

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