'Spare' Luteinizing Hormone Receptors: Facts and Fiction

被引：30
作者：
Casarini, Livio [1 ,2 ]
Santi, Daniele [1 ,3 ]
Simoni, Manuela [1 ,2 ,3 ]
Poti, Francesco [4 ]
机构：
[1] Univ Modena & Reggio Emilia, NOCSAE, Dept Biomed Metab & Neural Sci, Unit Endocrinol, Via P Giardini 1355, I-41126 Modena, Italy
[2] Univ Modena & Reggio Emilia, Ctr Genom Res, Via G Campi 287, I-41125 Modena, Italy
[3] Azienda Osped Univ Modena, NOCSAE, Dept Med Endocrinol Metab & Geriatr, Via P Giardini 1355, I-41126 Modena, Italy
[4] Univ Parma, Dept Med & Surg, Unit Neurosci, Via Volturno 39-F, I-43125 Parma, Italy
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 04期
关键词：
FOLLICLE-STIMULATING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; ASSISTED REPRODUCTIVE TECHNOLOGY; CELLS IN-VITRO; RAT TESTIS; OVARIAN STIMULATION; GRANULOSA-CELLS; LH RECEPTORS; BINDING; PROTEIN;
D O I：
10.1016/j.tem.2018.01.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is common opinion that maximal activation of luteinizing hormone (LH)-dependent steroidogenic signal occurs at < 1% of human LH/choriogonado-tropin (hCG) receptor (LHCGR) occupancy. This effect would be a consequence of an excess of receptors expressed on the surface of theca cells, resulting in a pool of LHCGRs remaining unbound (spare). This concept was borrowed from historical pharmacological studies, when discrepancies between ligand-receptor binding and dose-response curves of cAMP were evaluated by treating mouse or rat Leydig cells with hCG in vitro. Recent findings demonstrated the specificity of LH- and hCG-dependent effects, receptor heterodimerization, and differing behaviors of rodent versus human gonadotropin-responsive cells, which may help to revise the 'spare' LHCGRs concept applied to human ovarian physiology and assisted reproduction.
引用
收藏
页码：208 / 217
页数：10
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