'Spare' Luteinizing Hormone Receptors: Facts and Fiction

被引：30
作者：
Casarini, Livio [1 ,2 ]
Santi, Daniele [1 ,3 ]
Simoni, Manuela [1 ,2 ,3 ]
Poti, Francesco [4 ]
机构：
[1] Univ Modena & Reggio Emilia, NOCSAE, Dept Biomed Metab & Neural Sci, Unit Endocrinol, Via P Giardini 1355, I-41126 Modena, Italy
[2] Univ Modena & Reggio Emilia, Ctr Genom Res, Via G Campi 287, I-41125 Modena, Italy
[3] Azienda Osped Univ Modena, NOCSAE, Dept Med Endocrinol Metab & Geriatr, Via P Giardini 1355, I-41126 Modena, Italy
[4] Univ Parma, Dept Med & Surg, Unit Neurosci, Via Volturno 39-F, I-43125 Parma, Italy
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 04期
关键词：
FOLLICLE-STIMULATING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; ASSISTED REPRODUCTIVE TECHNOLOGY; CELLS IN-VITRO; RAT TESTIS; OVARIAN STIMULATION; GRANULOSA-CELLS; LH RECEPTORS; BINDING; PROTEIN;
D O I：
10.1016/j.tem.2018.01.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is common opinion that maximal activation of luteinizing hormone (LH)-dependent steroidogenic signal occurs at < 1% of human LH/choriogonado-tropin (hCG) receptor (LHCGR) occupancy. This effect would be a consequence of an excess of receptors expressed on the surface of theca cells, resulting in a pool of LHCGRs remaining unbound (spare). This concept was borrowed from historical pharmacological studies, when discrepancies between ligand-receptor binding and dose-response curves of cAMP were evaluated by treating mouse or rat Leydig cells with hCG in vitro. Recent findings demonstrated the specificity of LH- and hCG-dependent effects, receptor heterodimerization, and differing behaviors of rodent versus human gonadotropin-responsive cells, which may help to revise the 'spare' LHCGRs concept applied to human ovarian physiology and assisted reproduction.
引用
收藏
页码：208 / 217
页数：10
相关论文
共 61 条
[1]   Who needs LH in ovarian stimulation? [J].
Alviggi, C. ;
Clarizia, R. ;
Mollo, A. ;
Ranieri, A. ;
De Placido, G. .
REPRODUCTIVE BIOMEDICINE ONLINE, 2011, 22 :S33-S41
[2]   SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].
ARUNLAKSHANA, O ;
SCHILD, HO .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01) :48-58
[3]   Assessing gonadotropin receptor function by resonance energy transfer-based assays [J].
Ayoub, Mohammed Akli ;
Landomiel, Flavie ;
Gallay, Nathalie ;
Jegot, Gwenhael ;
Poupon, Anne ;
Crepieux, Pascale ;
Reiter, Eric .
FRONTIERS IN ENDOCRINOLOGY, 2015, 6
[4]  
Berque-Bestel Isabelle, 2008, Curr Drug Discov Technol, V5, P312, DOI 10.2174/157016308786733591
[5]  
BHALLA VK, 1987, J BIOL CHEM, V262, P5322
[6]   Class A GPCR heterodimers: evidence from binding studies [J].
Birdsall, Nigel J. M. .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2010, 31 (11) :499-508
[7]  
Bolander FF., 2004, MOL ENDOCRINOLOGY
[8]   SERUM HUMAN CHORIONIC-GONADOTROPIN LEVELS THROUGHOUT NORMAL-PREGNANCY [J].
BRAUNSTEIN, GD ;
RASOR, J ;
ADLER, D ;
DANZER, H ;
WADE, ME .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1976, 126 (06) :678-681
[9]   Clinical Applications of Gonadotropins in the Female: Assisted Reproduction and Beyond [J].
Casarini, L. ;
Brigante, G. ;
Simoni, M. ;
Santi, D. .
PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE, VOL 143: GONADOTROPINS: FROM BENCH SIDE TO BEDSIDE, 2016, 143 :85-119
[10]   Estrogen Modulates Specific Life and Death Signals Induced by LH and hCG in Human Primary Granulosa Cells In Vitro [J].
Casarini, Livio ;
Riccetti, Laura ;
De Pascali, Francesco ;
Gilioli, Lisa ;
Marino, Marco ;
Vecchi, Eugenia ;
Morini, Daria ;
Nicoli, Alessia ;
La Sala, Giovanni Battista ;
Simoni, Manuela .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)
1234567