Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19

被引：70
作者：
Robb, Calum T. [1 ]
Goepp, Marie [1 ]
Rossi, Adriano G. [1 ]
Yao, Chengcan [1 ]
机构：
[1] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh EH16 4TJ, Scotland
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 21期
基金：
英国医学研究理事会;
关键词：
COVID-19; cytokine storm; inflammation; NSAID; prostaglandin; SARS-CoV-2; NEUTROPHIL EXTRACELLULAR TRAPS; BRONCHOALVEOLAR LAVAGE FLUID; ENDOTHELIAL GROWTH-FACTOR; ACUTE LUNG INJURY; PROTEIN-KINASE-A; FACTOR-KAPPA-B; CYCLIC-AMP; NLRP3; INFLAMMASOME; SARS-CORONAVIRUS; DENDRITIC CELLS;
D O I：
10.1111/bph.15206
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine or efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain, and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxyganase enzymes. PGs can exert either proinflammatory or anti-inflammatory effects depending on the inflammatory scenario. In this review, we survey the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19.
引用
收藏
页码：4899 / 4920
页数：22
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