Effect of spironolactone on hypertrophy of left ventricular myocardium in Wistar rats with experimental uremia

被引：1
作者：
Karabayeva, A. Zh.
Esaian, A. M. [1 ]
Kayukov, I. G.
Parastaeva, M. M.
Beresneva, O. N.
Kotenko, L. V.
Sevastyanova, I. E.
机构：
[1] Fac Postgrad Educ, Dept Nephrol & Dialysis, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 06期
关键词：
aldosterone; spironolactone; arterial hypertension; left-ventricular hypertrophy;
D O I：
10.1007/s10517-008-0169-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chronic renal failure was modeled in rats by partial nephrectomy. Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated. In rats treated with spironolactone, the index of myocardial hypertrophy did not considerably differ from that in sham-operated animals, whereas in untreated rats the test parameters considerably differ from the control. We concluded that the blockade of aldosterone receptors with spironolactone produced a cardioprotective effect in Wistar rats with subtotal nephrectomy.
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收藏
页码：714 / 716
页数：3
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