Genomic features of attenuated Junin virus vaccine strain candidate

被引：33
作者：
Goñi, SE
Iserte, JA
Ambrosio, AM
Romanowski, V
Ghiringhelli, PD
Lozano, ME
机构：
[1] Univ Nacl Quilmes, Dept Ciencia & Tecnol, LIGBCM, RA-1876 Buenos Aires, DF, Argentina
[2] Inst Nacl Enfermedades Virales Humanas Dr Julio L, RA-2700 Pergamino, Argentina
[3] Natl Univ La Plata, Fac Ciencias Exactas, Dept Ciencias Biol, Inst Bioquim & Biol Mol, RA-1900 La Plata, Argentina
来源：
VIRUS GENES | 2006年 / 32卷 / 01期
关键词：
Arenaviridae; Junin; attenuation; molecular markers; L RNA; genomic;
D O I：
10.1007/s11262-005-5843-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.
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页码：37 / 41
页数：5
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