Huntington's disease

被引：72

作者：

Davies, S ^{[1
]}

Ramsden, DB ^{[1
]}

机构：

[1] Univ Birmingham, Dept Med, Div Med Sci, Birmingham B15 2TH, W Midlands, England

来源：

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2001年 / 54卷 / 06期

关键词：

Huntington's disease; neurodegenerative disorder; Huntingtin; NMDA receptors; kainate receptors;

D O I：

10.1136/mp.54.6.409

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The most recent findings in the elucidation of the molecular pathology of Huntington's disease are reviewed. Particular interest has been paid to the role of huntingtin and its associated proteins in excitotoxicity mediated via NMDA and kainate receptors.

引用

页码：409 / 413

页数：5

共 61 条

[1] No evidence for increased oxidative damage to lipids, proteins, or DNA in Huntington's disease [J].

Alam, ZI ;

Halliwell, B ;

Jenner, P .

JOURNAL OF NEUROCHEMISTRY, 2000, 75 (02) :840-846

[2] HEAT REPEATS IN THE HUNTINGTONS-DISEASE PROTEIN [J].

ANDRADE, MA ;

BORK, P .

NATURE GENETICS, 1995, 11 (02) :115-116

[3] Deficits in striatal dopamine D2 receptors and energy metabolism detected by in vivo MicroPET imaging in a rat model of Huntington's disease [J].

Araujo, DM ;

Cherry, SR ;

Tatsukawa, KJ ;

Toyokuni, T ;

Kornblum, HI .

EXPERIMENTAL NEUROLOGY, 2000, 166 (02) :287-297

[4] Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine [J].

Calabresi, P ;

Gubellini, P ;

Picconi, B ;

Centonze, D ;

Pisani, A ;

Bonsi, P ;

Greengard, P ;

Hipskind, RA ;

Borrelli, E ;

Bernardi, G .

JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5110-5120

[5] Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease [J].

Carmichael, J ;

Chatellier, J ;

Woolfson, A ;

Milstein, C ;

Fersht, AR ;

Rubinsztein, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) :9701-9705

[6] Loss of normal huntingtin function: new developments in Huntington's disease research [J].

Cattaneo, E ;

Rigamonti, D ;

Goffredo, D ;

Zuccato, C ;

Squitieri, F ;

Sipione, S .

TRENDS IN NEUROSCIENCES, 2001, 24 (03) :182-188

[7] Transcriptional dysregulation in Huntington's disease [J].

Cha, JHJ .

TRENDS IN NEUROSCIENCES, 2000, 23 (09) :387-392

[8] Changes in mRNA for post-synaptic density-95 (PSD-95) and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase following facial nerve transection [J].

Che, YH ;

Tamatani, M ;

Tohyama, M .

MOLECULAR BRAIN RESEARCH, 2000, 76 (02) :325-335

[9] Kainate receptors: subunits, synaptic localization and function [J].

Chittajallu, R ;

Braithwaite, SP ;

Clarke, VRJ ;

Henley, JM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (01) :26-35

[10] HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin [J].

Chopra, VS ;

Metzler, M ;

Rasper, DM ;

Engqvist-Goldstein, AEY ;

Singaraja, R ;

Gan, L ;

Fichter, KM ;

McCutcheon, K ;

Drubin, H ;

Nicholson, DW ;

Hayden, MR .

MAMMALIAN GENOME, 2000, 11 (11) :1006-1015

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