Acyclovir-resistant chronic verrucous vaccine strain varicella in a patient with neuroblastoma

被引：16

作者：

Bryan, Coleman J. ^{[1
]}

Prichard, Mark N. ^{[2
]}

Daily, Shannon ^{[2
]}

Jefferson, Geraldine ^{[2
]}

Hartline, Caroll ^{[2
]}

Cassady, Kevin A. ^{[2
]}

Hilliard, Lee ^{[1
]}

Shimamura, Masako ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Div Pediat Hematol Oncol, Birmingham, AL USA

[2] Univ Alabama Birmingham, Div Pediat Infect Dis, Birmingham, AL USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 10期

关键词：

varicella; Oka; acyclovir; resistance; immunosuppressed; neuroblastoma;

D O I：

10.1097/INF.0b013e318175d85c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 21-month-old girl with neuroblastoma developed chronic verrucous Oka strain varicella-zoster infection during chemotherapy. Virus isolated from the patient demonstrated high-level acyclovir resistance, and its thymidine kinase had no in vitro enzymatic activity. After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation. This is only the second reported case of resistant varicella zoster virus caused by Oka strain virus.

引用

页码：946 / 948

页数：3

共 15 条

[11] Selective phosphorylation of antiviral drugs by vaccinia virus thyraidine kinase [J].

Prichard, Mark N. ;

Keith, Kathy A. ;

Johnson, Mary P. ;

Harden, Emma A. ;

McBrayer, Alexis ;

Luo, Ming ;

Qiu, Shihong ;

Chattopadhyay, Debasish ;

Fan, Xuesen ;

Torrence, Paul F. ;

Kern, Earl R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (05) :1795-1803

[12] Clinical and virologic characterization of acyclovir-resistant varicella-zoster viruses isolated from 11 patients with acquired immunodeficiency syndrome [J].

Saint-Léger, E ;

Caumes, E ;

Breton, G ;

Douard, D ;

Saiag, P ;

Huraux, JM ;

Bricaire, F ;

Agut, H ;

Fillet, AM .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (12) :2061-2067

[13] The postmarketing safety profile of varicella vaccine [J].

Sharrar, RG ;

LaRussa, P ;

Galea, SA ;

Steinberg, SP ;

Sweet, AR ;

Keatley, RM ;

Wells, ME ;

Stephenson, WP ;

Gershon, AA .

VACCINE, 2000, 19 (7-8) :916-923

[14] SUSCEPTIBILITY OF OKA VARICELLA VACCINE STRAIN TO ANTIVIRAL DRUGS [J].

SHIRAKI, K ;

MATSUI, S ;

AIBA, N .

VACCINE, 1993, 11 (14) :1380-1382

[15] Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro [J].

Williams-Aziz, SL ;

Hartline, CB ;

Harden, EA ;

Daily, SL ;

Prichard, MN ;

Kushner, NL ;

Beadle, JR ;

Wan, WB ;

Hostetler, KY ;

Kern, ER .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (09) :3724-3733

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