Acyclovir-resistant chronic verrucous vaccine strain varicella in a patient with neuroblastoma

被引：16

作者：

Bryan, Coleman J. ^{[1
]}

Prichard, Mark N. ^{[2
]}

Daily, Shannon ^{[2
]}

Jefferson, Geraldine ^{[2
]}

Hartline, Caroll ^{[2
]}

Cassady, Kevin A. ^{[2
]}

Hilliard, Lee ^{[1
]}

Shimamura, Masako ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Div Pediat Hematol Oncol, Birmingham, AL USA

[2] Univ Alabama Birmingham, Div Pediat Infect Dis, Birmingham, AL USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 10期

关键词：

varicella; Oka; acyclovir; resistance; immunosuppressed; neuroblastoma;

D O I：

10.1097/INF.0b013e318175d85c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 21-month-old girl with neuroblastoma developed chronic verrucous Oka strain varicella-zoster infection during chemotherapy. Virus isolated from the patient demonstrated high-level acyclovir resistance, and its thymidine kinase had no in vitro enzymatic activity. After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation. This is only the second reported case of resistant varicella zoster virus caused by Oka strain virus.

引用

页码：946 / 948

页数：3

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