Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence

被引:69
作者
Silva-Adaya, Daniela [1 ]
Gonsebatt, Maria E. [2 ]
Guevara, Jorge [3 ]
机构
[1] Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerat, Mexico City 14269, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico
[3] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, DF, Mexico
关键词
LEUKEMIA-DERIVED FACTOR; PROTEIN DISULFIDE-ISOMERASE; EARLY EMBRYONIC LETHALITY; OXIDATIVE STRESS MARKER; ALZHEIMERS-DISEASE; INTERACTING PROTEIN; REDOX REGULATION; ANTIOXIDANT THIOREDOXIN-2; MITOCHONDRIAL DYSFUNCTION; PHYSIOLOGICAL FUNCTIONS;
D O I
10.1155/2014/590808
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS is composed of thioredoxin, thioredoxin reductase, and NADPH. This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed. Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part.
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页数:13
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