Comparison of SPE, IFE, and FLC in Monitoring Patients with Multiple Myeloma After Autologous Stem Cell Transplantation

被引：3

作者：

Li, Wei ^{[1
,2
]}

Zhou, Jia-Zi ^{[3
,4
,5
,6
]}

Chang, Hui-Rong ^{[3
,4
,5
,6
]}

Dai, Li-Jun ^{[3
,4
,5
,6
]}

Zhu, Zi-Ling ^{[3
,4
,5
,6
]}

Feng, Yu-Feng ^{[3
,4
,5
,6
]}

Gong, Fei-Ran ^{[3
,4
,5
,6
]}

Wu, De-Pei ^{[3
,4
,5
,6
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Oncol, Suzhou 215006, Peoples R China

[2] Soochow Univ, PREMED Key Lab Precis Med, Suzhou 215006, Peoples R China

[3] Soochow Univ, Affiliated Hosp 1, Dept Hematol, Suzhou 215006, Peoples R China

[4] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Suzhou 215006, Peoples R China

[5] Soochow Univ, Collaborat Innovat Ctr Hematol, Suzhou 215006, Peoples R China

[6] Soochow Univ, Affiliated Hosp 1, Minist Hlth, Key Lab Thrombosis & Hemostasis, Suzhou 215006, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 73卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Multiple myeloma; ASCT; Serum FLC ratio; Serum IFE; SPE; LIGHT-CHAIN ASSAYS; PROTEIN BANDS; SERUM; DIAGNOSIS; GUIDELINES; EVOLUTION; CRITERIA; THERAPY; KAPPA;

D O I：

10.1007/s12013-015-0655-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Conventionally, serum protein electrophoresis (SPE) and serum immunofixation electrophoresis (IFE) are used as primary methods to diagnose and monitor multiple myeloma (MM). Recently, serum-free light chain (FLC) assay has been incorporated into hematological screening programs for myeloma. The purpose of this study is to compare the performance of the three methods in monitoring MM patients after autologous stem cell transplantation (ASCT). SPE, serum IFE and serum FLC assay were performed on 38 MM patients who underwent ASCT. In total, four patients had unexpected protein bands (UPBs) and 13 patients had relapsed after ASCT. Our results indicate that IFE is more sensitive than SPE and FLC assay in detection of UPBs and relapse. The results of IFE may provide useful information in advance of patient relapse.

引用

页码：643 / 647

页数：5

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