Chemodiversity and biological activity of essential oils from three species from theEuphorbiagenus

被引：15

作者：

Sinan, Kouadio Ibrahime ^{[1
]}

Etienne, Ouattara Katinan ^{[2
]}

Stefanucci, Azzurra ^{[3
]}

Mollica, Adriano ^{[3
]}

Mahomoodally, Mohamad Fawzi ^{[4
]}

Jugreet, Sharmeen ^{[4
]}

Rocchetti, Gabriele ^{[5
]}

Lucini, Luigi ^{[5
]}

Aktumsek, Abdurrahman ^{[1
]}

Montesano, Domenico ^{[6
]}

Ak, Gunes ^{[1
]}

Zengin, Gokhan ^{[1
]}

机构：

[1] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey

[2] Univ Felix Houphouet Boigny, Lab Bot, UFR Biosci, Abidjan, Cote Ivoire

[3] Univ G dAnnunzio, Dept Pharm, Chieti, Italy

[4] Univ Mauritius, Fac Med & Hlth Sci, Dept Hlth Sci, Reduit, Mauritius

[5] Univ Cattolica Sacro Cuore, Dept Sustainable Food Proc, Piacenza, Italy

[6] Univ Perugia, Food Sci & Nutr Sect, Dept Pharmaceut Sci, Via S Costanzo 1, I-06126 Perugia, Italy

来源：

FLAVOUR AND FRAGRANCE JOURNAL | 2021年 / 36卷 / 01期

关键词：

anti-cholinesterase; anti-tyrosinase; essential oil; Euphorbia; molecular docking; TYROSINASE INHIBITORY-ACTIVITY; CHEMICAL-COMPOSITION; BETA-CARYOPHYLLENE; EUPHORBIA-HIRTA; ANTIOXIDANT ACTIVITIES; ALZHEIMERS-DISEASE; CYTOTOXIC ACTIVITY; CRUDE EXTRACTS; CONSTITUENTS; PROTEIN;

D O I：

10.1002/ffj.3624

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Several studies demonstrated the wide pharmacological properties of extracts and essential oils (EOs) prepared fromEuphorbiaspecies. In the present study, the chemical composition and biological activities of EOs from three differentEuphorbiaspecies were evaluated using in vitro methods. A total of 29, 33 and 42 constituents were identified in the EOs ofE hirta,E convolvuloidesandE heterophylla, respectively. The EOs exhibited in vitro radical scavenging potential in the ABTS assay (2.89-21.50 mg/g). Additionally, an inhibitory effect on acetylcholinesterase (4.23-5.12 mg/g) was detected. Besides, remarkable tyrosinase inhibition was reported by the EOs (95.24-113.74 mg/g). Molecular docking was also performed to elucidate the binding interactions between selected EO components and enzymes. Phytol and geranyl-(E)-acetone had a good binding with tyrosinase in the molecular docking. This study highlighted the promising pharmacological profiles of these EOs as natural sources of antioxidants as well as cholinesterase and tyrosinase inhibitors that could be further explored in the management of human ailments in food and pharmaceutical industries.

引用

页码：148 / 158

页数：11

共 76 条

[1] Multiple factor analysis: principal component analysis for multitable and multiblock data sets [J].