Chronic traumatic encephalopathy: Diagnostic updates and advances

被引：13

作者：

Pierre, Kevin ^{[1
]}

Molina, Vanessa ^{[2
]}

Shukla, Shil ^{[2
]}

Avila, Anthony ^{[2
]}

Fong, Nicholas ^{[2
]}

Nguyen, Jessica ^{[2
]}

Lucke-Wold, Brandon ^{[3
]}

机构：

[1] Univ Florida, Dept Radiol, Gainesville, FL 32603 USA

[2] Sam Houston State Univ Osteopath Med, Conroe, TX 77304 USA

[3] Univ Florida, Dept Neurosurg, Gainesville, FL 32603 USA

来源：

AIMS NEUROSCIENCE | 2022年 / 9卷 / 04期

关键词：

chronic traumatic encephalopathy; diagnostics; work up; management; MILD COGNITIVE IMPAIRMENT; NEUROFIBRILLARY PATHOLOGY; ALZHEIMERS-DISEASE; TAU PATHOLOGY; BRAIN-INJURY; PLAYERS; SINGLE; PET; DYSFUNCTION; DISRUPTION;

D O I：

10.3934/Neuroscience.2022030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs secondary to repetitive mild traumatic brain injury. Current clinical diagnosis relies on symptomatology and structural imaging findings which often vary widely among those with the disease. The gold standard of diagnosis is post-mortem pathological examination. In this review article, we provide a brief introduction to CTE, current diagnostic workup and the promising research on imaging and fluid biomarker diagnostic techniques. For imaging, we discuss quantitative structural analyses, DTI, fMRI, MRS, SWI and PET CT. For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.

引用

页码：519 / 535

页数：17

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