Nanomolar Determination of Methyldopa in the Presence of Large Amounts of Hydrochlorothiazide Using a Carbon Paste Electrode Modified with Graphene Oxide Nanosheets and 3-(4-Amino-3-hydroxy-biphenyl-4-yl)-acrylic Acid

被引：25

作者：

Mohammadi, Seyed Zia ^{[1
]}

Beitollahi, Hadi ^{[2
]}

Jasemi, Malihe ^{[1
]}

Akbari, Ali ^{[3
]}

机构：

[1] Payame Noor Univ, Dept Chem, Tehran, Iran

[2] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Dept Environm, Kerman, Iran

[3] Univ Jiroft, Dept Chem, Jiroft, Iran

来源：

ELECTROANALYSIS | 2015年 / 27卷 / 10期

关键词：

Methyldopa; Hydrochlorothiazide; Graphene oxide nanosheets; Voltammetry; Drug analysis; SIMULTANEOUS ELECTROCHEMICAL DETERMINATION; SELECTIVE DETERMINATION; TITRIMETRIC DETERMINATION; 1ST REPORT; SPECTROPHOTOMETRIC DETERMINATION; PHARMACEUTICAL-PREPARATIONS; VOLTAMMETRIC BEHAVIOR; ALPHA-METHYLDOPA; HUMAN PLASMA; HUMAN SERUM;

D O I：

10.1002/elan.201500245

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel electrochemical sensor for sensitive detection of methyldopa at physiological pH was developed by the bulk modification of carbon paste electrode (CPE) with graphene oxide nanosheets and 3-(4-amino-3-hydroxy-biphenyl-4-yl)-acrylic acid (3,AA). Applying square wave voltammetry (SWV), in phosphate buffer solution (PBS) of pH7.0, the oxidation current increased linearly with two concentration intervals of methyldopa, one is 1.0x10(-8)-1.0x10(-6)M and the other is 1.0x10(-6)-4.5x10(-5)M. The detection limit (3 sigma) obtained by SWV was 9.0nM. The modified electrode was successfully applied for simultaneous determination of methyldopa and hydrochlorothiazide. Finally, the proposed method was applied to the determination of methyldopa and hydrochlorothiazide in some real samples.

引用

页码：2421 / 2430

页数：10

共 54 条

[1] Flow injection-spectrophotometeric determination of some catecholamine drugs in pharmaceutical preparations via oxidative coupling reaction with p-toluidine and sodium periodate [J].