Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

被引：33

作者：

Liu, B

Han, Y

Corey, DR

Kodadek, T

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 09期

关键词：

D O I：

10.1021/ja0164226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site. Copyright © 2002 American Chemical Society.

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页码：1838 / 1839

页数：2

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