Comparison of specificities between two interferon-gamma release assays in Japan

被引：20
|
作者：
Higuchi, K. [1 ]
Sekiya, Y.
Igari, H. [2 ,3 ]
Watanabe, A. [2 ]
Harada, N.
机构：
[1] Japan AntiTB Assoc, Res Inst TB, Dept Mycobacterium Reference & Res, Kiyose, Tokyo 2048533, Japan
[2] Chiba Univ Hosp, Chiba, Japan
[3] East Hosp, Natl Hosp Org, Chiba, Japan
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2012年 / 16卷 / 09期
关键词：
tuberculosis; IGRAs; specificity; MYCOBACTERIUM-TUBERCULOSIS INFECTION; RAPID DETECTION; T-CELLS; ENUMERATION; INDIVIDUALS; DIAGNOSIS; DISEASE;
D O I：
10.5588/ijtld.11.0829
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We compared the specificities of two interferon-gamma release assays (IGRAs), T-SPOT (R).TB (T-SPOT) and the QuantiFERON (R)-TB Gold In-Tube (QFT-GIT) assay, in strictly selected subjects with a low risk of tuberculosis (TB) infection in a Japanese population. Of 111 subjects who were mostly bacille Calmette-Guerin vaccinated, one was positive using both assays and 110 were negative, using international cut-off values. Although several meta-analyses report that QFT-GIT has higher specificity than T-SPOT, our study demonstrates that the specificity of both assays is equally high in a population with a truly low risk of TB infection.
引用
收藏
页码：1190 / 1192
页数：3
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