Comparison of specificities between two interferon-gamma release assays in Japan

被引：20

作者：

Higuchi, K. ^{[1
]}

Sekiya, Y.

Igari, H. ^{[2
,3
]}

Watanabe, A. ^{[2
]}

Harada, N.

机构：

[1] Japan AntiTB Assoc, Res Inst TB, Dept Mycobacterium Reference & Res, Kiyose, Tokyo 2048533, Japan

[2] Chiba Univ Hosp, Chiba, Japan

[3] East Hosp, Natl Hosp Org, Chiba, Japan

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2012年 / 16卷 / 09期

关键词：

tuberculosis; IGRAs; specificity; MYCOBACTERIUM-TUBERCULOSIS INFECTION; RAPID DETECTION; T-CELLS; ENUMERATION; INDIVIDUALS; DIAGNOSIS; DISEASE;

D O I：

10.5588/ijtld.11.0829

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We compared the specificities of two interferon-gamma release assays (IGRAs), T-SPOT (R).TB (T-SPOT) and the QuantiFERON (R)-TB Gold In-Tube (QFT-GIT) assay, in strictly selected subjects with a low risk of tuberculosis (TB) infection in a Japanese population. Of 111 subjects who were mostly bacille Calmette-Guerin vaccinated, one was positive using both assays and 110 were negative, using international cut-off values. Although several meta-analyses report that QFT-GIT has higher specificity than T-SPOT, our study demonstrates that the specificity of both assays is equally high in a population with a truly low risk of TB infection.

引用

页码：1190 / 1192

页数：3

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