Bakuchiol:: A hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells

被引：66

作者：

Cho, H

Jun, JY

Song, EK

Kang, KH

Baek, HY

Ko, YS

Kim, YC ^{[1
]}

机构：

[1] Wonkwang Univ, MRRC, Iksan 570749, South Korea

[2] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

[3] Jungwoo Pharmaceut Co, Asan, Chungnam, South Korea

[4] Korea Food & Drug Adm, Kwangju, South Korea

来源：

PLANTA MEDICA | 2001年 / 67卷 / 08期

关键词：

D O I：

10.1055/s-2001-18347

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the H2O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 - 3 are 1.0, 47.0, 50.0 mug/ml, respectively. Silymarin as a positive control showed the EC50 value with 5.0 mug/ml.

引用

页码：750 / 751

页数：2

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