Short- and Long-Term Evaluation of Renal Function after Radical Cystectomy and Cutaneous Ureterostomy in High-Risk Patients

被引：12

作者：

Creta, Massimiliano ^{[1
]}

Fusco, Ferdinando ^{[2
]}

La Rocca, Roberto ^{[1
]}

Capece, Marco ^{[1
]}

Celentano, Giuseppe ^{[1
]}

Imbimbo, Ciro ^{[1
]}

Imperatore, Vittorio ^{[3
]}

Russo, Luigi ^{[4
]}

Mangiapia, Francesco ^{[1
]}

Mirone, Vincenzo ^{[1
]}

Russo, Domenico ^{[5
]}

Longo, Nicola ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Sci Reprod & Odontostomatol, Urol Sect, I-80131 Naples, Italy

[2] Luigi Vanvitelli Univ Naples, Dept Urol, I-80131 Naples, Italy

[3] Buon Consiglio Fatebenefratelli Hosp, Urol Unit, I-80123 Naples, Italy

[4] Osped Mare, Nephrol Unit, I-80131 Naples, Italy

[5] Univ Naples Federico II, Nephrol Unit, Dept Publ Hlth, I-80131 Naples, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 07期

关键词：

renal function; acute kidney injury; GFR deterioration; bladder cancer; radical cystectomy; cutaneous ureterostomy; CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; BLADDER-CANCER; FUNCTION OUTCOMES; ILEAL CONDUIT; PERIOPERATIVE OUTCOMES; URINARY-DIVERSION; MORBIDITY; STANDARD; IMPACT;

D O I：

10.3390/jcm9072191

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deterioration of renal function has been reported after radical cystectomy (RC) with urinary diversion. We investigated renal function changes in elderly bladder cancer (BCa) patients who underwent RC with cutaneous ureterostomy (CU) urinary diversion. We performed a retrospective, observational study. BCa patients aged >= 75 with an American Society of Anesthesiologists (ASA) class greater than II were included. Glomerular filtration rate (GFR) was the main outcome measure. GFR values were recorded preoperatively, at discharge, at 6-month follow-up, and yearly up to 60 months. A total of 70 patients with a median age of 78.0 years were identified. Median preoperative GFR was 74.3 mL/min/1.73 m(2)and declined significantly to 54.6 mL/min/1.73 m(2)after 6 months (p< 0.001). A gradual GFR decline was observed thereafter, reaching a median value of 46.2 after 60 months. Preoperative GFR and acute kidney injury were significant predictors of fast deterioration of GFR and of 25% deterioration of GFR after 12 months. Elderly BCa patients with high comorbidity rates undergoing RC with CU should be carefully informed about the risk of GFR deterioration and the need for adequate monitoring.

引用

页码：1 / 9

页数：9

共 25 条

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