Subacute toxicity assessment of carotenoids extracted from citrus peel (Nanfengmiju, Citrus reticulata Blanco) in rats

被引：12

作者：

Xue, Feng ^{[1
]}

Li, Chen ^{[2
]}

Pan, Siyi ^{[1
]}

机构：

[1] Huazhong Agr Univ, Dept Food Sci & Technol, Wuhan 430070, Peoples R China

[2] Jiangnan Univ, State Key Lab Food Sci & Technol, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2012年 / 62卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Carotenoids; Citrus peel; Subacute toxicity; LYCOPENE;

D O I：

10.1016/j.yrtph.2011.12.003

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The mixture of carotenoids extracted from citrus peel (Nanfengmiju, Citrus reticulata Blanco) was tested for subacute oral toxicity. In this study, dose levels of 0, 200, 500 and 2000 mg/kg body weight/day were administered by gavage to 10 Wistar rats/sex/group for 28 days. No statistically significant, dose-related effect on food consumption, food efficiency, body weight gain, clinical signs or ophthalmoscopic parameters was observed in any treatment group. Urinalysis, hematological, blood coagulation and serum biochemical examination as well as necropsy or histopathology showed that no observed adverse effect was found. These findings suggested that the No-Observed-Adverse-Effect Level for the mixture of carotenoids extracted from citrus peel was at least 2000 mg/kg body weight/day. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：16 / 22

页数：7

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