Neuroprotective strategies following intraparenchymal hemorrhage

被引：17

作者：

Babadjouni, Robin Moshe ^{[1
]}

Radwanski, Ryan E. ^{[1
]}

Walcott, Brian P. ^{[2
]}

Patel, Arati ^{[1
]}

Durazo, Ramon ^{[1
]}

Hodis, Drew M. ^{[1
]}

Emanuel, Benjamin A. ^{[2
]}

Mack, William J. ^{[1
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Neurosurg, Los Angeles, CA USA

来源：

JOURNAL OF NEUROINTERVENTIONAL SURGERY | 2017年 / 9卷 / 12期

关键词：

SPONTANEOUS INTRACEREBRAL HEMORRHAGE; MINIMALLY INVASIVE SURGERY; ACTIVATED FACTOR-VII; BLOOD-BRAIN-BARRIER; TRANEXAMIC ACID; STATIN USE; ANTIFIBRINOLYTIC AGENT; PLATELET ACTIVITY; CONTROLLED-TRIAL; STROKE;

D O I：

10.1136/neurintsurg-2017-013197

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Intracerebral hemorrhage and, more specifically, intraparenchymal hemorrhage, are devastating disease processes with poor clinical outcomes. Primary injury to the brain results from initial hematoma expansion while secondary hemorrhagic injury occurs from blood-derived products such as hemoglobin, heme, iron, and coagulation factors that overwhelm the brains natural defenses. Novel neuroprotective treatments have emerged that target primary and secondary mechanisms of injury. Nonetheless, translational application of neuroprotectants from preclinical to clinical studies has yet to show beneficial clinical outcomes. This review summarizes therapeutic agents and neuroprotectants in ongoing clinical trials aimed at targeting primary and secondary mechanisms of injury after intraparenchymal hemorrhage.

引用

页码：1202 / +

页数：7

共 91 条

[1] Animal models of spontaneous intracerebral hemorrhage [J].

Alharbi, Bader Murshed ;

Tso, Michael K. ;

Macdonald, R. Loch .

NEUROLOGICAL RESEARCH, 2016, 38 (05) :448-455

[2] Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage [J].

Anderson, Craig S. ;

Heeley, Emma ;

Huang, Yining ;

Wang, Jiguang ;

Stapf, Christian ;

Delcourt, Candice ;

Lindley, Richard ;

Robinson, Thompson ;

Lavados, Pablo ;

Neal, Bruce ;

Hata, Jun ;

Arima, Hisatomi ;

Parsons, Mark ;

Li, Yuechun ;

Wang, Jinchao ;

Heritier, Stephane ;

Li, Qiang ;

Woodward, Mark ;

Simes, R. John ;

Davis, Stephen M. ;

Chalmers, John .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (25) :2355-2365

[3] Efficacy and Safety of Oral Conivaptan, a Vasopressin-Receptor Antagonist, Evaluated in a Randomized, Controlled Trial in Patients With Euvolemic or Hypervolemic Hyponatremia [J].

Annane, Djillali ;

Decaux, Guy ;

Smith, Neila .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2009, 337 (01) :28-36

[4] Cyclooxygenase-2 inhibitor NS-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity [J].

Araki, E ;

Forster, C ;

Dubinsky, JM ;

Ross, ME ;

Iadecola, C .

STROKE, 2001, 32 (10) :2370-2375

[5]

Arkin S, 2016, AM SOC HEMATOLOGY

[6] Molecular Pathophysiology of Cerebral Hemorrhage Secondary Brain Injury [J].

Aronowski, Jaroslaw ;

Zhao, Xiurong .

STROKE, 2011, 42 (06) :1781-1786

[7]

Arumugam A, 2015, MALAYS J MED SCI, V22, P62

[8] Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death [J].

Arumugam, Thiruma V. ;

Tang, Sung-Chun ;

Lathia, Justin D. ;

Cheng, Aiwu ;

Mughal, Mohamed R. ;

Chigurupati, Srinivasulu ;

Magnus, Tim ;

Chan, Sic L. ;

Jo, Dong-Gyu ;

Ouyang, Xin ;

Fairlie, David P. ;

Granger, Daniel N. ;

Vortmeyer, Alexander ;

Basta, Milan ;

Mattson, Mark P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :14104-14109

[9] Neuroprotective delivery platforms as an adjunct to mechanical thrombectomy [J].

Babadjouni, Robin M. ;

Walcott, Brian P. ;

Liu, Qinghai ;

Tenser, Matthew S. ;

Amar, Arun P. ;

Mack, William J. .

NEUROSURGICAL FOCUS, 2017, 42 (04)

[10] Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after Intracerebral Hemorrhage: From Benchwork to Practical Aspects [J].

Babi, Marc-Alain ;

James, Michael L. .

FRONTIERS IN NEUROLOGY, 2017, 8

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