Stem cell therapies and regenerative medicine in China

被引:13
作者
Huang Sha [1 ,2 ,3 ]
Fu XiaoBing [1 ,2 ]
机构
[1] Chinese Peoples Liberat Army Gen Hosp, Inst Basic Med Sci, Wound Healing & Cell Biol Lab, Beijing 100853, Peoples R China
[2] Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Key Lab Wound Repair & Regenerat Med PLA, Beijing 100048, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
基金
中国国家自然科学基金;
关键词
stem cells; regenerative medicine; tissue engineering; clinical trial; UMBILICAL-CORD BLOOD; BONE-MARROW; TRANSPLANTATION; MECHANISMS; PLURIPOTENT; PROMISE; TRIALS; REPAIR;
D O I
10.1007/s11427-014-4608-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Stem cells are the core of tissue repair and regeneration, and a promising cell source for novel therapies. In recent years, research into stem cell therapies has been particularly exciting in China. The remarkable advancements in basic stem cell research and clinically effective trials have led to fresh insights into regenerative medicine, such as treatments for sweat gland injury after burns, diabetes, and liver injury. High hopes have inspired numerous experimental and clinical trials. At the same time, government investment and policy support of research continues to increase markedly. However, numerous challenges must be overcome before novel stem cell therapies can achieve meaningful clinical outcomes.
引用
收藏
页码:157 / 161
页数:5
相关论文
共 36 条
[1]   Regulation of stem cell therapies under attack in Europe: for whom the bell tolls [J].
Bianco, Paolo ;
Barker, Roger ;
Bruestle, Oliver ;
Cattaneo, Elena ;
Clevers, Hans ;
Daley, George Q. ;
De Luca, Michele ;
Goldstein, Lawrence ;
Lindvall, Olle ;
Mummery, Christine ;
Robey, Pamela G. ;
de Sousa e Brito, Clara Sattler ;
Smith, Austin .
EMBO JOURNAL, 2013, 32 (11) :1489-1495
[2]   Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction [J].
Chen, SL ;
Fang, W ;
Ye, F ;
Liu, YH ;
Qian, J ;
Shan, S ;
Zhang, J ;
Zhao, RCH ;
Liao, LM ;
Lin, S ;
Sun, JP .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (01) :92-95
[3]   Signalling pathways that control vertebrate haematopoietic stem cell specification [J].
Clements, Wilson K. ;
Traver, David .
NATURE REVIEWS IMMUNOLOGY, 2013, 13 (05) :336-348
[4]   Human umbilical cord blood stem cells, myocardial infarction and stroke [J].
Copeland, Nathan ;
Harris, David ;
Gaballa, Mohamed A. .
CLINICAL MEDICINE, 2009, 9 (04) :342-345
[5]   The Promise and Perils of Stem Cell Therapeutics [J].
Daley, George Q. .
CELL STEM CELL, 2012, 10 (06) :740-749
[6]   Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy [J].
Gnecchi, Massimiliano ;
Zhang, Zhiping ;
Ni, Aiguo ;
Dzau, Victor J. .
CIRCULATION RESEARCH, 2008, 103 (11) :1204-1219
[7]   Exploring the application of mesenchymal stem cells in bone repair and regeneration [J].
Griffin, M. ;
Iqbal, S. A. ;
Bayat, A. .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2011, 93B (04) :427-434
[8]   FDA regulation of stem-cell-based therapies [J].
Halme, Dina Gould ;
Kessler, David A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (16) :1730-1735
[9]   Non-haematological uses of cord blood stem cells [J].
Harris, David T. .
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 147 (02) :177-184
[10]   New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research [J].
Hyun, Insoo ;
Lindvall, Olle ;
Ahrlund-Richter, Lars ;
Cattaneo, Elena ;
Cavazzana-Calvo, Marina ;
Cossu, Giulio ;
De Luca, Michele ;
Fox, Ira J. ;
Gerstle, Claude ;
Goldstein, Robert A. ;
Hermeren, Goran ;
High, Katherine A. ;
Kim, Hyun Ok ;
Lee, Hin Peng ;
Levy-Lahad, Ephrat ;
Li, Lingsong ;
Lo, Bernard ;
Marshak, Daniel R. ;
McNab, Angela ;
Munsie, Megan ;
Nakauchi, Hiromitsu ;
Rao, Mahendra ;
Rooke, Heather M. ;
Valles, Carlos Simon ;
Srivastava, Alok ;
Sugarman, Jeremy ;
Taylor, Patrick L. ;
Veiga, Anna ;
Wong, Adrianne L. ;
Zoloth, Laurie ;
Daley, George Q. .
CELL STEM CELL, 2008, 3 (06) :607-609