Exploring Concentration Response in HIV Pre-Exposure Prophylaxis to Optimize Clinical Care and Trial Design

被引：56

作者：

Hendrix, Craig W. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med Clin Pharmacol, Baltimore, MD 21287 USA

来源：

CELL | 2013年 / 155卷 / 03期

关键词：

ANTIRETROVIRAL PROPHYLAXIS; PREVENTION; TENOFOVIR; INFECTION; ACCEPTABILITY;

D O I：

10.1016/j.cell.2013.09.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV pre-exposure prophylaxis trials with antiretroviral drugs have been variably successful. Even trials demonstrating the best efficacy leave room for improvement. Pharmacological data illuminate several sources of outcome variability, especially the impact of poor adherence, which is critical to manage PrEP in the clinic and to develop the next generation of PrEP candidates.

引用

页码：515 / 518

页数：4

共 19 条

[1] Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men [J].

Anderson, Peter L. ;

Glidden, David V. ;

Liu, Albert ;

Buchbinder, Susan ;

Lama, Javier R. ;

Vicente Guanira, Juan ;

McMahan, Vanessa ;

Bushman, Lane R. ;

Casapia, Martin ;

Montoya-Herrera, Orlando ;

Veloso, Valdilea G. ;

Mayer, Kenneth H. ;

Chariyalertsak, Suwat ;

Schechter, Mauro ;

Bekker, Linda-Gail ;

Kallas, Esper Georges ;

Grant, Robert M. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (151)

[2]

[Anonymous], 2007, AIDS

[3]

Anton PA, 2012, AIDS RES HUM RETROV, V28, P1412, DOI [10.1089/aid.2012.0262, 10.1089/AID.2012.0262]

[4] Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women [J].

Baeten, J. M. ;

Donnell, D. ;

Ndase, P. ;

Mugo, N. R. ;

Campbell, J. D. ;

Wangisi, J. ;

Tappero, J. W. ;

Bukusi, E. A. ;

Cohen, C. R. ;

Katabira, E. ;

Ronald, A. ;

Tumwesigye, E. ;

Were, E. ;

Fife, K. H. ;

Kiarie, J. ;

Farquhar, C. ;

John-Stewart, G. ;

Kakia, A. ;

Odoyo, J. ;

Mucunguzi, A. ;

Nakku-Joloba, E. ;

Twesigye, R. ;

Ngure, K. ;

Apaka, C. ;

Tamooh, H. ;

Gabona, F. ;

Mujugira, A. ;

Panteleeff, D. ;

Thomas, K. K. ;

Kidoguchi, L. ;

Krows, M. ;

Revall, J. ;

Morrison, S. ;

Haugen, H. ;

Emmanuel-Ogier, M. ;

Ondrejcek, L. ;

Coombs, R. W. ;

Frenkel, L. ;

Hendrix, C. ;

Bumpus, N. N. ;

Bangsberg, D. ;

Haberer, J. E. ;

Stevens, W. S. ;

Lingappa, J. R. ;

Celum, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (05) :399-410

[5] Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study [J].

Chen, Jianmeng ;

Flexner, Charles ;

Liberman, Rosa G. ;

Skipper, Paul L. ;

Louissaint, Nicolette A. ;

Tannenbaum, Steven R. ;

Hendrix, Craig W. ;

Fuchs, Edward J. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 61 (05) :593-599

[6] Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial [J].

Choopanya, Kachit ;

Martin, Michael ;

Suntharasamai, Pravan ;

Sangkum, Udomsak ;

Mock, Philip A. ;

Leethochawalit, Manoj ;

Chiamwongpaet, Sithisat ;

Kitisin, Praphan ;

Natrujirote, Pitinan ;

Kittimunkong, Somyot ;

Chuachoowong, Rutt ;

Gvetadze, Roman J. ;

McNicholl, Janet M. ;

Paxton, Lynn A. ;

Curlin, Marcel E. ;

Hendrix, Craig W. ;

Vanichseni, Suphak .

LANCET, 2013, 381 (9883) :2083-2090

[7] Prevention of HIV-1 Infection with Early Antiretroviral Therapy [J].

Cohen, Myron S. ;

Chen, Ying Q. ;

McCauley, Marybeth ;

Gamble, Theresa ;

Hosseinipour, Mina C. ;

Kumarasamy, Nagalingeswaran ;

Hakim, James G. ;

Kumwenda, Johnstone ;

Grinsztejn, Beatriz ;

Pilotto, Jose H. S. ;

Godbole, Sheela V. ;

Mehendale, Sanjay ;

Chariyalertsak, Suwat ;

Santos, Breno R. ;

Mayer, Kenneth H. ;

Hoffman, Irving F. ;

Eshleman, Susan H. ;

Piwowar-Manning, Estelle ;

Wang, Lei ;

Makhema, Joseph ;

Mills, Lisa A. ;

de Bruyn, Guy ;

Sanne, Ian ;

Eron, Joseph ;

Gallant, Joel ;

Havlir, Diane ;

Swindells, Susan ;

Ribaudo, Heather ;

Elharrar, Vanessa ;

Burns, David ;

Taha, Taha E. ;

Nielsen-Saines, Karin ;

Celentano, David ;

Essex, Max ;

Fleming, Thomas R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) :493-505

[8] Pharmacokinetics and Pharmacodynamics of the Reverse Transcriptase Inhibitor Tenofovir and Prophylactic Efficacy against HIV-1 Infection [J].

Duwal, Sulav ;

Schuette, Christof ;

von Kleist, Max .

PLOS ONE, 2012, 7 (07)

[9] The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection [J].

Gardner, Edward M. ;

McLees, Margaret P. ;

Steiner, John F. ;

del Rio, Carlos ;

Burman, William J. .

CLINICAL INFECTIOUS DISEASES, 2011, 52 (06) :793-800

[10] Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men. [J].

Grant, Robert M. ;

Lama, Javier R. ;

Anderson, Peter L. ;

McMahan, Vanessa ;

Liu, Albert Y. ;

Vargas, Lorena ;

Goicochea, Pedro ;

Casapia, Martin ;

Guanira-Carranza, Juan Vicente ;

Ramirez-Cardich, Maria E. ;

Montoya-Herrera, Orlando ;

Fernandez, Telmo ;

Veloso, Valdilea G. ;

Buchbinder, Susan P. ;

Chariyalertsak, Suwat ;

Schechter, Mauro ;

Bekker, Linda-Gail ;

Mayer, Kenneth H. ;

Kallas, Esper Georges ;

Amico, K. Rivet ;

Mulligan, Kathleen ;

Bushman, Lane R. ;

Hance, Robert J. ;

Ganoza, Carmela ;

Defechereux, Patricia ;

Postle, Brian ;

Wang, Furong ;

McConnell, J. Jeff ;

Zheng, Jia-Hua ;

Lee, Jeanny ;

Rooney, James F. ;

Jaffe, Howard S. ;

Martinez, Ana I. ;

Burns, David N. ;

Glidden, David V. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (27) :2587-2599

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