Copper-Catalyzed Cross-Coupling of Secondary -Haloamides with Terminal Alkynes: Access to Diverse 2,3-Allenamides

被引：6
|
作者：
Lv, Yunhe [1 ,2 ]
Pu, Weiya [1 ]
Zhu, Xueli [1 ]
Zhao, Tiantian [1 ]
Lin, Feifei [1 ]
机构：
[1] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang 455000, Peoples R China
[2] Henan Prov Key Lab New Optoelect Funct Mat, Anyang 455000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 07期
关键词：
Alkynes; copper; cross-coupling; -haloamides; trisubstituted allenes; ONE-POT SYNTHESIS; PROPARGYLIC ALCOHOLS; EFFICIENT SYNTHESIS; 1,3-DISUBSTITUTED ALLENES; TRISUBSTITUTED ALLENES; ROOM-TEMPERATURE; CHIRAL ALLENES; ENANTIOSELECTIVE SYNTHESIS; SYNTHETIC APPLICATIONS; SONOGASHIRA REACTIONS;
D O I：
10.1002/adsc.201701556
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A copper-catalyzed C(sp)-C(sp(3)) cross-coupling of terminal alkynes with readily available secondary -haloamides for the efficient synthesis of 2,3-allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for synthesizing allenes. A mechanism involving an alkynylcopper species is proposed.
引用
收藏
页码：1397 / 1401
页数：5
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