Immune control of Staphylococcus aureus - Regulation and counter-regulation of the adaptive immune response

被引：51
作者：
Broeker, Barbara M. [1 ]
Holtfreter, Silva [1 ]
Bekeredjian-Ding, Isabelle [2 ]
机构：
[1] Univ Med Greifswald, Dept Immunol, D-17475 Greifswald, Germany
[2] Univ Bonn, Inst Med Microbiol Immunol & Parasitol, Bonn, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2014年 / 304卷 / 02期
关键词：
Staphylococcus aureus; T cells; B cells; antibodies; immune memory; TOXIC-SHOCK-SYNDROME; B-CELL SUPERANTIGEN; EXTRACELLULAR PROTEIN-A; FC-ALPHA-RI; METHICILLIN-RESISTANT; T-CELLS; NASAL CARRIAGE; ANTIBODY-RESPONSE; BINDING PROTEIN; INFECTIOUS COMPLICATIONS;
D O I：
10.1016/j.ijmm.2013.11.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Successful vaccination relies on immune memory, a core competence of the adaptive immune system. This review summarizes the current knowledge about the adaptive immune response to Staphylococcus aureus as well as the bacterial escape mechanisms. The Janus-faced bacteria, both life-threatening pathogens and peaceful cohabitants of their human host, have so far frustrated all attempts at vaccine development. This begs the question of whether the adaptive immune system is at all able to protect against S. aureus infection. In search of an answer the main functions of the adaptive immune system are probed for potential mechanisms of protection against S. aureus, which may be put to the test in future research. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：204 / 214
页数：11
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