Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells

被引：142

作者：

Freedman, Bethany D. ^{[1
,2
]}

Kempna, Petra Bukovac ^{[1
,2
]}

Carlone, Diana L. ^{[1
,2
]}

Shah, Manasvi S. ^{[1
,2
]}

Guagliardo, Nick A. ^{[3
]}

Barrett, Paula Q. ^{[3
]}

Gomez-Sanchez, Celso E. ^{[4
]}

Majzoub, Joseph A. ^{[1
,2
]}

Breault, David T. ^{[1
,2
,5
]}

机构：

[1] Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA

[4] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

[5] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

来源：

DEVELOPMENTAL CELL | 2013年 / 26卷 / 06期

关键词：

STEROIDOGENIC FACTOR-I; NUCLEAR RECEPTOR; ADRENAL-CORTEX; BETA-CELLS; X-ZONE; MICE; EXPRESSION; ALDOSTERONE; FETAL; GLAND;

D O I：

10.1016/j.devcel.2013.07.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lineage conversion of differentiated cells in response to hormonal feedback has yet to be described. To investigate this, we studied the adrenal cortex, which is composed of functionally distinct concentric layers that develop postnatally, the outer zona glomerulosa (zG) and the inner zona fasciculata (zF). These layers have separate functions, are continuously renewed in response to physiological demands, and are regulated by discrete hormonal feedback loops. Their cellular origin, lineage relationship, and renewal mechanism, however, remain poorly understood. Cell-fate mapping and gene-deletion studies using zG-specific Cre expression demonstrate that differentiated zG cells undergo lineage conversion into zF cells. In addition, zG maintenance is dependent on the master transcriptional regulator Steroidogenic Factor 1 (SF-1), and zG-specific Sf-1 deletion prevents lineage conversion. These findings demonstrate that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues.

引用

页码：666 / 673

页数：8

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