Clinical multiphoton tomography

被引：283

作者：

Koenig, Karsten ^{[1
,2
,3
]}

机构：

[1] Univ Saarland, Fac Mechatron & Phys, D-66123 Saarbrucken, Germany

[2] Jenlab GmbH, D-07745 Jena, Germany

[3] Fraunhofer IBMT, D-66386 St Ingbert, Germany

来源：

JOURNAL OF BIOPHOTONICS | 2008年 / 1卷 / 01期

关键词：

multiphoton tomography; two-photon; femtosecond laser; melanoma; skin;

D O I：

10.1002/jbio.200710022

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Clinical multiphoton tomography and two-photon micro-endoscopy provide clinicians and researchers with high-resolution in vivo optical biopsies based on two-photon autofluorescence, second harmonic generation, and fluorescence lifetime imaging. This review reflects state of the art technology and reports on applications in the fields of early stage melanoma detection, skin aging, nanoparticle imaging, tissue engineering,, and in situ screening of pharmaceutical and cosmetical products. So far, more than 500 patients and volunteers in Europe, Asia, and Australia have been investigated with these novel molecular imaging, tools. [GRAPHICS] State-of-the-art images from a human nevus of a female volunteer obtained with dermatoscopy, ultrasound, OCT, and confocal reflection microscopy (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：13 / 23

页数：11

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